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10.1038/srep32587 http://scihub22266oqcxt.onion/10.1038/srep32587 C5009328!5009328 !27585971     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27585971 &cmd=llinks): Failed to open stream: HTTP request failed! 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Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome |pdf=|usr=}}{{27585971 }} gab.com Text Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27585971 #FOAvip The inflammasome is a large, multiprotein complex that consists of a nucleotide-binding oligomerization domain-like receptor (NLR), an apoptosis-associated speck-like protein containing a caspase recruitment domain, and pro-caspase-1. Activation of the inflammasome results in cleavage of pro-caspase-1 into cleaved caspase-1, which promotes the processing of pro-interleukin (IL)-1? into mature IL-1?. We investigated the effects of colchicine on non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury and activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome. Colchicine treatment inhibited indomethacin-induced small intestinal injury by 86% (1?mg/kg) and 94% (3?mg/kg) as indicated by the lesion index 24?h after indomethacin administration. Colchicine inhibited the protein expression of cleaved caspase-1 and mature IL-1?, without affecting the mRNA expression of NLRP3 and IL-1?. Although treatment with recombinant IL-1? (0.1??g/kg) did not change the severity of small intestinal damage, the preventive effects of colchicine were abolished by supplementation with the same dose of recombinant IL-1?. Indomethacin-induced small intestinal damage was reduced by 77%, as determined by the lesion index in NLRP3(-/-) mice, and colchicine treatment failed to inhibit small intestinal damage in NLRP3(-/-) mice. These results demonstrate that colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Twit Text FOAVip Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27585971 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27585971 #FOAvip English Wikipedia <ref>{{Cite pmid|27585971 }}</ref> Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome #MMPMID27585971 Otani K ; Watanabe T ; Shimada S ; Takeda S ; Itani S ; Higashimori A ; Nadatani Y ; Nagami Y ; Tanaka F ; Kamata N ; Yamagami H ; Tanigawa T ; Shiba M ; Tominaga K ; Fujiwara Y ; Arakawa T Sci Rep 2016[Sep]; 6 (ä): 32587 PMID27585971 show ga The inflammasome is a large, multiprotein complex that consists of a nucleotide-binding oligomerization domain-like receptor (NLR), an apoptosis-associated speck-like protein containing a caspase recruitment domain, and pro-caspase-1. Activation of the inflammasome results in cleavage of pro-caspase-1 into cleaved caspase-1, which promotes the processing of pro-interleukin (IL)-1? into mature IL-1?. We investigated the effects of colchicine on non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury and activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome. Colchicine treatment inhibited indomethacin-induced small intestinal injury by 86% (1?mg/kg) and 94% (3?mg/kg) as indicated by the lesion index 24?h after indomethacin administration. Colchicine inhibited the protein expression of cleaved caspase-1 and mature IL-1?, without affecting the mRNA expression of NLRP3 and IL-1?. Although treatment with recombinant IL-1? (0.1??g/kg) did not change the severity of small intestinal damage, the preventive effects of colchicine were abolished by supplementation with the same dose of recombinant IL-1?. Indomethacin-induced small intestinal damage was reduced by 77%, as determined by the lesion index in NLRP3(-/-) mice, and colchicine treatment failed to inhibit small intestinal damage in NLRP3(-/-) mice. These results demonstrate that colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. |Animals [MESH] |Anti-Inflammatory Agents, Non-Steroidal/*adverse effects [MESH] |Caspase 1/metabolism [MESH] |Colchicine/*pharmacology [MESH] |Indomethacin/administration & dosage/adverse effects [MESH] |Inflammasomes/*metabolism [MESH] |Interleukin-1beta/pharmacology [MESH] |Intestine, Small/drug effects/enzymology/*injuries/pathology [MESH] |Mice, Inbred C57BL [MESH]Colchicine prevents NSAID-induced small intestinal injury by inhibitin(epmc).pdf DeepDyve Pubget Overpricing