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10.1038/srep32545 http://scihub22266oqcxt.onion/10.1038/srep32545 C5009300!5009300!27585918     free     free     free       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27585918|t=2016. Astragaloside IV ameliorates renal injury in db/db mice |pdf=|usr=}}{{27585918}} gab.com Text Astragaloside IV ameliorates renal injury in db/db mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27585918 #FOAvip Diabetic nephropathy is a lethal complication of diabetes mellitus and a major type of chronic kidney disease. Dysregulation of the Akt pathway and its downstream cascades, including mTOR, NF?B, and Erk1/2, play a critical role in the development of diabetic nephropathy. Astragaloside IV is a major component of Huangqi and exerts renal protection in a mouse model of type 1 diabetes. The current study was undertaken to investigate the protective effects of diet supplementation of AS-IV on renal injury in db/db mice, a type 2 diabetic mouse model. Results showed that administration of AS-IV reduced albuminuria, ameliorated changes in the glomerular and tubular pathology, and decreased urinary NAG, NGAL, and TGF-?1 in db/db mice. AS-IV also attenuated the diabetes-related activation of Akt/mTOR, NF?B, and Erk1/2 signaling pathways without causing any detectable hepatotoxicity. Collectively, these findings showed AS-IV to be beneficial to type 2 diabetic nephropathy, which might be associated with the inhibition of Akt/mTOR, NF?B and Erk1/2 signaling pathways. Twit Text FOAVip Astragaloside IV ameliorates renal injury in db/db mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27585918 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27585918 #FOAvip English Wikipedia <ref>{{Cite pmid|27585918}}</ref> Astragaloside IV ameliorates renal injury in db/db mice #MMPMID27585918 Sun H; Wang W; Han P; Shao M; Song G; Du H; Yi T; Li S Sci Rep 2016[]; 6 (ä): ä PMID27585918show ga Diabetic nephropathy is a lethal complication of diabetes mellitus and a major type of chronic kidney disease. Dysregulation of the Akt pathway and its downstream cascades, including mTOR, NF?B, and Erk1/2, play a critical role in the development of diabetic nephropathy. Astragaloside IV is a major component of Huangqi and exerts renal protection in a mouse model of type 1 diabetes. The current study was undertaken to investigate the protective effects of diet supplementation of AS-IV on renal injury in db/db mice, a type 2 diabetic mouse model. Results showed that administration of AS-IV reduced albuminuria, ameliorated changes in the glomerular and tubular pathology, and decreased urinary NAG, NGAL, and TGF-?1 in db/db mice. AS-IV also attenuated the diabetes-related activation of Akt/mTOR, NF?B, and Erk1/2 signaling pathways without causing any detectable hepatotoxicity. Collectively, these findings showed AS-IV to be beneficial to type 2 diabetic nephropathy, which might be associated with the inhibition of Akt/mTOR, NF?B and Erk1/2 signaling pathways. äAstragaloside IV ameliorates renal injury in db/db mice (epmc).pdf DeepDyve Pubget Overpricing