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10.1111/jdi.12505 http://scihub22266oqcxt.onion/10.1111/jdi.12505 C5009129!5009129 !27180929     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27180929 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Diabetes+Investig 2016 ; 7 (5 ): 680-8 Nephropedia Template TP {{tp|p=27180929 |t=2016. Vitamin D and its receptor regulate lipopolysaccharide-induced transforming growth factor-?, angiotensinogen expression and podocytes apoptosis through the nuclear factor-?B pathway |pdf=|usr=}}{{27180929 }} gab.com Text Vitamin D and its receptor regulate lipopolysaccharide-induced transforming growth factor- , angiotensinogen expression and podocytes apoptosis through the nuclear factor- B pathway JO: J Diabetes Investig http://www.kidney.de/pget.php?&tw=1&pmid=27180929 #FOAvip AIMS/INTRODUCTION: To investigate the effects of vitamin D and its receptor on cytokines expression and podocytes apoptosis. MATERIALS AND METHODS: Cultured mouse podocytes were pre-incubated with vitamin D or transiently transfected with small interfering ribonucleic acid (RNA) to knock down the vitamin D receptor. Lipopolysaccharide was used to mimic the inflammation status of diabetes. RESULTS: In a lipopolysaccharide-induced state, expressions of transforming growth factor-?, angiotensinogen and vascular endothelial growth factor were similarly increased. Transforming growth factor-? and angiotensinogen levels originally elevated by lipopolysaccharide challenge were distinctly reduced after pre-incubation with vitamin D. Whereas after vitamin D receptor small interfering (si)RNA transfection, the aforementioned cytokines had opposite changes as expected. However, neither vitamin D pretreatment nor vitamin D receptor siRNA transfection influenced the previously increased vascular endothelial growth factor expression at messenger RNA or protein levels. When pretreated with vitamin D, decreases were observed for phosphorylated inhibitor-?B and the inhibitor kinase proteins. After siRNA transfection, those proteins levels were further elevated. The originally increased transforming growth factor-? and angiotensinogen levels as a result of lipopolysaccharide stimulation were reduced at both the messenger RNA and protein levels after the specific inhibition of the nuclear factor-?B pathway with pyrrolidine dithiocarbamate. The apoptosis rate of podocytes was decreased in a parallel manner after vitamin D pre-incubation, and increased after siRNA transfection, which was also suppressed by pyrrolidine dithiocarbamate. CONCLUSIONS: Vitamin D and its receptor might be involved in the progression of diabetic nephropathy by regulating transforming growth factor-?, angiotensinogen expression and apoptosis of podocytes. The processes are mediated through the signaling of nuclear factor-?B pathway. Twit Text FOAVip Vitamin D and its receptor regulate lipopolysaccharide-induced transforming growth factor- , angiotensinogen expression and podocytes apoptosis through the nuclear factor- B pathway ????J Diabetes Investig http://www.kidney.de/pget.php?&tw=1&pmid=27180929 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27180929 #FOAvip English Wikipedia <ref>{{Cite pmid|27180929 }}</ref> Vitamin D and its receptor regulate lipopolysaccharide-induced transforming growth factor-?, angiotensinogen expression and podocytes apoptosis through the nuclear factor-?B pathway #MMPMID27180929 Xu L ; Zhang P ; Guan H ; Huang Z ; He X ; Wan X ; Xiao H ; Li Y J Diabetes Investig 2016[Sep]; 7 (5 ): 680-8 PMID27180929 show ga AIMS/INTRODUCTION: To investigate the effects of vitamin D and its receptor on cytokines expression and podocytes apoptosis. MATERIALS AND METHODS: Cultured mouse podocytes were pre-incubated with vitamin D or transiently transfected with small interfering ribonucleic acid (RNA) to knock down the vitamin D receptor. Lipopolysaccharide was used to mimic the inflammation status of diabetes. RESULTS: In a lipopolysaccharide-induced state, expressions of transforming growth factor-?, angiotensinogen and vascular endothelial growth factor were similarly increased. Transforming growth factor-? and angiotensinogen levels originally elevated by lipopolysaccharide challenge were distinctly reduced after pre-incubation with vitamin D. Whereas after vitamin D receptor small interfering (si)RNA transfection, the aforementioned cytokines had opposite changes as expected. However, neither vitamin D pretreatment nor vitamin D receptor siRNA transfection influenced the previously increased vascular endothelial growth factor expression at messenger RNA or protein levels. When pretreated with vitamin D, decreases were observed for phosphorylated inhibitor-?B and the inhibitor kinase proteins. After siRNA transfection, those proteins levels were further elevated. The originally increased transforming growth factor-? and angiotensinogen levels as a result of lipopolysaccharide stimulation were reduced at both the messenger RNA and protein levels after the specific inhibition of the nuclear factor-?B pathway with pyrrolidine dithiocarbamate. The apoptosis rate of podocytes was decreased in a parallel manner after vitamin D pre-incubation, and increased after siRNA transfection, which was also suppressed by pyrrolidine dithiocarbamate. CONCLUSIONS: Vitamin D and its receptor might be involved in the progression of diabetic nephropathy by regulating transforming growth factor-?, angiotensinogen expression and apoptosis of podocytes. The processes are mediated through the signaling of nuclear factor-?B pathway. |*Apoptosis/drug effects [MESH] |Angiotensinogen/*metabolism [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Inflammation/chemically induced/*metabolism [MESH] |Lipopolysaccharides [MESH] |Mice [MESH] |NF-kappa B/*metabolism [MESH] |Podocytes/drug effects/*metabolism [MESH] |Receptors, Calcitriol/*metabolism [MESH] |Signal Transduction/drug effects [MESH] |Transforming Growth Factor beta/*metabolism [MESH]Vitamin D and its receptor regulate lipopolysaccharide-induced transfo(epmc).pdf DeepDyve Pubget Overpricing