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2016 ; 16
(6
): 903-12
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Insular atrophy and diminished disgust reactivity
#MMPMID27148847
Verstaen A
; Eckart JA
; Muhtadie L
; Otero MC
; Sturm VE
; Haase CM
; Miller BL
; Levenson RW
Emotion
2016[Sep]; 16
(6
): 903-12
PMID27148847
show ga
Disgust is an emotion that helps us deal with potential contamination (Rozin &
Fallon, 1987). It produces a distinctive facial expression (e.g., wrinkled nose)
and a physiological response that is accompanied by strong visceral sensations
(e.g., nausea). Given the important role that the anterior insula plays in
processing and integrating visceral information (Craig, 2009), it is likely to be
centrally involved in disgust. Despite this, few studies have examined the link
between insular degeneration and the experience, physiology, and expression of
disgust. We studied a group that was heterogeneous in terms of insular damage: 84
patients with neurodegenerative diseases (i.e., frontotemporal dementia,
corticobasal syndrome, progressive supranuclear palsy, Alzheimer's disease) and
29 controls. Subjects viewed films that elicit high levels of disgust and
sadness. Emotional reactivity was assessed using self-report, peripheral
physiology, and facial behavior. Regional brain volumes (insula, putamen,
pallidum, caudate, and amygdala) were determined from structural MRIs using the
FreeSurfer method. Results indicated that smaller insular volumes were associated
with reduced disgust responding in self-report and physiological reactivity, but
not in facial behavior. In terms of the specificity of these findings, insular
volume did not predict sadness reactivity, and disgust reactivity was not
predicted by putamen, pallidum, and caudate volumes (lower self-reported disgust
was associated with smaller amygdala volume). These findings underscore the
central role of the insula in the experience and physiology of disgust. (PsycINFO
Database Record
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