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10.1038/tpj.2016.4 http://scihub22266oqcxt.onion/10.1038/tpj.2016.4 C5009007!5009007 !26927285     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26927285 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Pharmacogenomics+J 2017 ; 17 (2 ): 192-200 Nephropedia Template TP {{tp|p=26927285 |t=2017. A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials |pdf=|usr=}}{{26927285 }} gab.com Text A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials JO: Pharmacogenomics J http://www.kidney.de/pget.php?&tw=1&pmid=26927285 #FOAvip We conducted a meta-analysis of pharmacogenomic substudies of three randomized trials conducted in patients with decompensated heart failure (HF) that were led by National Heart Lung and Blood Institute (NHLBI)-funded HF Network to test the hypothesis that candidate genes modulate net fluid loss and weight change in patients with decompensated HF treated with a furosemide-based diuretic regimen. Although none of the genetic variants previously shown to modulate the effects of loop diuretics in healthy individuals were associated with net fluid loss after 72?h of treatment, a set of rare variants in the APOL1 gene, which codes for apolipoprotein L1 (P=0.0005 in the random effects model), was associated with this end point. Moreover, a common variant in the multidrug resistance protein-4 coding gene (ABCC4, rs17268282) was associated with weight loss with furosemide use (P=0.0001). Our results suggest that both common and rare genetic variants modulate the response to a furosemide-based diuretic regimen in patients with decompensated HF. Twit Text FOAVip A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials ????Pharmacogenomics J http://www.kidney.de/pget.php?&tw=1&pmid=26927285 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26927285 #FOAvip English Wikipedia <ref>{{Cite pmid|26927285 }}</ref> A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials #MMPMID26927285 de Denus S ; Rouleau JL ; Mann DL ; Huggins GS ; Cappola TP ; Shah SH ; Keleti J ; Zada YF ; Provost S ; Bardhadi A ; Phillips MS ; Normand V ; Mongrain I ; Dubé MP Pharmacogenomics J 2017[Mar]; 17 (2 ): 192-200 PMID26927285 show ga We conducted a meta-analysis of pharmacogenomic substudies of three randomized trials conducted in patients with decompensated heart failure (HF) that were led by National Heart Lung and Blood Institute (NHLBI)-funded HF Network to test the hypothesis that candidate genes modulate net fluid loss and weight change in patients with decompensated HF treated with a furosemide-based diuretic regimen. Although none of the genetic variants previously shown to modulate the effects of loop diuretics in healthy individuals were associated with net fluid loss after 72?h of treatment, a set of rare variants in the APOL1 gene, which codes for apolipoprotein L1 (P=0.0005 in the random effects model), was associated with this end point. Moreover, a common variant in the multidrug resistance protein-4 coding gene (ABCC4, rs17268282) was associated with weight loss with furosemide use (P=0.0001). Our results suggest that both common and rare genetic variants modulate the response to a furosemide-based diuretic regimen in patients with decompensated HF. |*Pharmacogenomic Variants [MESH] |*Polymorphism, Single Nucleotide [MESH] |Administration, Intravenous [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Apolipoprotein L1 [MESH] |Apolipoproteins/*genetics [MESH] |Clinical Trials as Topic [MESH] |Female [MESH] |Fluid Shifts/drug effects [MESH] |Furosemide/*administration & dosage [MESH] |Genotype [MESH] |Heart Failure/diagnosis/*drug therapy/genetics/physiopathology [MESH] |Humans [MESH] |Lipoproteins, HDL/*genetics [MESH] |Male [MESH] |Middle Aged [MESH] |Multidrug Resistance-Associated Proteins/*genetics [MESH] |Pharmacogenetics [MESH] |Phenotype [MESH] |Sodium Potassium Chloride Symporter Inhibitors/*administration & dosage [MESH] |Time Factors [MESH] |Treatment Outcome [MESH]A pharmacogenetic investigation of intravenous furosemide in decompens(epmc).pdf DeepDyve Pubget Overpricing