Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1371/journal.pone.0161867 http://scihub22266oqcxt.onion/10.1371/journal.pone.0161867 C5008626!5008626!27583546     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2016 ; 11 (9): ä Nephropedia Template TP {{tp|p=27583546|t=2016. C5a Induces the Synthesis of IL-6 and TNF-? in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways |pdf=|usr=}}{{27583546}} gab.com Text C5a Induces the Synthesis of IL-6 and TNF- in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27583546 #FOAvip Inflammatory response has been reported to contribute to the renal lesions in rat Thy-1 nephritis (Thy-1N) as an animal model of human mesangioproliferative glomerulonephritis (MsPGN). Besides C5b-9 complex, C5a is also a potent pro-inflammatory mediator and correlated to severity of various nephritic diseases. However, the role of C5a in mediating pro-inflammatory cytokine production in rats with Thy-1N is poorly defined. In the present studies, the levels of C5a, interleukin-6 (IL-6) and tumor necrosis factor-? (TNF-?) were first determined in the renal tissues of rats with Thy-1N. Then, the expression of IL-6 and TNF-? was detected in rat glomerular mesangial cells (GMC) stimulated with our recombinant rat C5a in vitro. Subsequently, the activation of mitogen-activated protein kinase (MAPK) signaling pathways (p38 MAPK, ERK1/2 and JNK) and their roles in the regulation of IL-6 and TNF-? production were examined in the GMC induced by C5a. The results showed that the levels of C5a, IL-6 and TNF-? were markedly increased in the renal tissues of Thy-1N rats. Rat C5a stimulation in vitro could up-regulate the expression of IL-6 and TNF-? in rat GMC, and the activation of MAPK signaling pathways was involved in the induction of IL-6 and TNF-?. Mechanically, p38 MAPK activation promoted IL-6 production, while either ERK1/2 or JNK activation promoted TNF-? production in the GMC with exposure to C5a. Taken together, these data implicate that C5a induces the synthesis of IL-6 and TNF-? in rat GMC through the activation of MAPK signaling pathways. Twit Text FOAVip C5a Induces the Synthesis of IL-6 and TNF- in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27583546 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27583546 #FOAvip English Wikipedia <ref>{{Cite pmid|27583546}}</ref> C5a Induces the Synthesis of IL-6 and TNF-? in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways #MMPMID27583546 Ji M; Lu Y; Zhao C; Gao W; He F; Zhang J; Zhao D; Qiu W; Wang Y PLoS One 2016[]; 11 (9): ä PMID27583546show ga Inflammatory response has been reported to contribute to the renal lesions in rat Thy-1 nephritis (Thy-1N) as an animal model of human mesangioproliferative glomerulonephritis (MsPGN). Besides C5b-9 complex, C5a is also a potent pro-inflammatory mediator and correlated to severity of various nephritic diseases. However, the role of C5a in mediating pro-inflammatory cytokine production in rats with Thy-1N is poorly defined. In the present studies, the levels of C5a, interleukin-6 (IL-6) and tumor necrosis factor-? (TNF-?) were first determined in the renal tissues of rats with Thy-1N. Then, the expression of IL-6 and TNF-? was detected in rat glomerular mesangial cells (GMC) stimulated with our recombinant rat C5a in vitro. Subsequently, the activation of mitogen-activated protein kinase (MAPK) signaling pathways (p38 MAPK, ERK1/2 and JNK) and their roles in the regulation of IL-6 and TNF-? production were examined in the GMC induced by C5a. The results showed that the levels of C5a, IL-6 and TNF-? were markedly increased in the renal tissues of Thy-1N rats. Rat C5a stimulation in vitro could up-regulate the expression of IL-6 and TNF-? in rat GMC, and the activation of MAPK signaling pathways was involved in the induction of IL-6 and TNF-?. Mechanically, p38 MAPK activation promoted IL-6 production, while either ERK1/2 or JNK activation promoted TNF-? production in the GMC with exposure to C5a. Taken together, these data implicate that C5a induces the synthesis of IL-6 and TNF-? in rat GMC through the activation of MAPK signaling pathways. äC5a Induces the Synthesis of IL-6 and TNF-? in Rat Glomerular Mesangia(epmc).pdf DeepDyve Pubget Overpricing