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10.18632/oncotarget.7947 http://scihub22266oqcxt.onion/10.18632/oncotarget.7947 C5008362!5008362 !26967245     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26967245 &cmd=llinks): Failed to open stream: HTTP request failed! 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Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach |pdf=|usr=}}{{26967245 }} gab.com Text Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26967245 #FOAvip The epithelial to mesenchymal transition (EMT) program is activated in epithelial cancer cells and facilitates their ability to metastasize based on enhanced migratory, proliferative, anti-apoptotic, and pluripotent capacities. Given the fundamental impact of sphingolipid machinery to each individual process, the sphingolipid-related mechanisms might be considered among the most prominent drivers/players of EMT; yet, there is still limited knowledge. Given the complexity of the interconnected sphingolipid system, which includes distinct sphingolipid mediators, their synthesizing enzymes, receptors and transporters, we herein apply an integrative approach for assessment of the sphingolipid-associated mechanisms underlying EMT program. We created the sphingolipid-/EMT-relevant 41-gene/23-gene signatures which were applied to denote transcriptional events in a lung cancer cell-based EMT model. Based on defined 35-gene sphingolipid/EMT-attributed signature of regulated genes, we show close associations between EMT markers, genes comprising the sphingolipid network at multiple levels and encoding sphingosine 1-phosphate (S1P)-/ceramide-metabolizing enzymes, S1P and lysophosphatidic acid (LPA) receptors and S1P transporters, pluripotency genes and inflammation-related molecules, and demonstrate the underlying biological pathways and regulators. Mass spectrometry-based sphingolipid analysis revealed an EMT-attributed shift towards increased S1P and LPA accompanied by reduced ceramide levels. Notably, using transcriptomics data across various cell-based perturbations and neoplastic tissues (24193 arrays), we identified the sphingolipid/EMT signature primarily in lung adenocarcinoma tissues; besides, bladder, colorectal and prostate cancers were among the top-ranked. The findings also highlight novel regulatory associations between influenza virus and the sphingolipid/EMT-associated mechanisms. In sum, data propose the multidimensional contribution of sphingolipid machinery to pathological EMT and may yield new biomarkers and therapeutic targets. Twit Text FOAVip Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26967245 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26967245 #FOAvip English Wikipedia <ref>{{Cite pmid|26967245 }}</ref> Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach #MMPMID26967245 Meshcheryakova A ; Svoboda M ; Tahir A ; Köfeler HC ; Triebl A ; Mungenast F ; Heinze G ; Gerner C ; Zimmermann P ; Jaritz M ; Mechtcheriakova D Oncotarget 2016[Apr]; 7 (16 ): 22295-323 PMID26967245 show ga The epithelial to mesenchymal transition (EMT) program is activated in epithelial cancer cells and facilitates their ability to metastasize based on enhanced migratory, proliferative, anti-apoptotic, and pluripotent capacities. Given the fundamental impact of sphingolipid machinery to each individual process, the sphingolipid-related mechanisms might be considered among the most prominent drivers/players of EMT; yet, there is still limited knowledge. Given the complexity of the interconnected sphingolipid system, which includes distinct sphingolipid mediators, their synthesizing enzymes, receptors and transporters, we herein apply an integrative approach for assessment of the sphingolipid-associated mechanisms underlying EMT program. We created the sphingolipid-/EMT-relevant 41-gene/23-gene signatures which were applied to denote transcriptional events in a lung cancer cell-based EMT model. Based on defined 35-gene sphingolipid/EMT-attributed signature of regulated genes, we show close associations between EMT markers, genes comprising the sphingolipid network at multiple levels and encoding sphingosine 1-phosphate (S1P)-/ceramide-metabolizing enzymes, S1P and lysophosphatidic acid (LPA) receptors and S1P transporters, pluripotency genes and inflammation-related molecules, and demonstrate the underlying biological pathways and regulators. Mass spectrometry-based sphingolipid analysis revealed an EMT-attributed shift towards increased S1P and LPA accompanied by reduced ceramide levels. Notably, using transcriptomics data across various cell-based perturbations and neoplastic tissues (24193 arrays), we identified the sphingolipid/EMT signature primarily in lung adenocarcinoma tissues; besides, bladder, colorectal and prostate cancers were among the top-ranked. The findings also highlight novel regulatory associations between influenza virus and the sphingolipid/EMT-associated mechanisms. In sum, data propose the multidimensional contribution of sphingolipid machinery to pathological EMT and may yield new biomarkers and therapeutic targets. |Cell Line, Tumor [MESH] |Epithelial-Mesenchymal Transition/*physiology [MESH] |Gene Regulatory Networks [MESH] |Humans [MESH] |Lipid Metabolism [MESH] |Neoplasms/metabolism/*pathology [MESH] |Sphingolipids/genetics/*metabolism [MESH]Exploring the role of sphingolipid machinery during the epithelial to (epmc).pdf DeepDyve Pubget Overpricing