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10.18632/oncotarget.7895 http://scihub22266oqcxt.onion/10.18632/oncotarget.7895 C5008345!5008345!26956045     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (16): 22077-91 Nephropedia Template TP {{tp|p=26956045|t=2016. The TGF-? pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells |pdf=|usr=}}{{26956045}} gab.com Text The TGF- pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26956045 #FOAvip TGF-? pathway is generally associated with the processes of metastasis, angiogenesis and EMT in cancer. Very little is known, however, about the role of TGF-? in cancer drug resistance. In this work, we show a specific activation of the TGF-? pathway in consequence of chemotherapeutic treatment in in vivo and in vitro models of colorectal carcinoma. 5-Fluorouracil (5FU) was able to stimulate the activation of SMAD3 and the transcription of specific genes such as ACVRL1, FN1 and TGFB1. On the other hand, the specific inhibition of TGF-?RI was able to repress the 5FU-induced genes transcription and to restore the sensitivity of chemoresistant cells to the toxic action of the drug, by decreasing the expression of BCL2L1 and ID1 genes. The role of the TGF-? molecule in the chemoresistant colon carcinoma cells' response to 5FU was further demonstrated by conditioned medium (CM) experiments: CM from 5FU-treated chemoresistant cells was able to protect chemosensitive cells against the toxic action of 5FU. In conclusion, these findings showed the pivotal role of TGF-? pathway in colon cancer mechanisms of drug resistance suggesting new possible approaches in diagnosis and treatment of colon cancer patients. Twit Text FOAVip The TGF- pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26956045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26956045 #FOAvip English Wikipedia <ref>{{Cite pmid|26956045}}</ref> The TGF-? pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells #MMPMID26956045 Romano G; Santi L; Bianco MR; Giuffrè MR; Pettinato M; Bugarin C; Garanzini C; Savarese L; Leoni S; Cerrito MG; Leone BE; Gaipa G; Grassilli E; Papa M; Lavitrano M; Giovannoni R Oncotarget 2016[Apr]; 7 (16): 22077-91 PMID26956045show ga TGF-? pathway is generally associated with the processes of metastasis, angiogenesis and EMT in cancer. Very little is known, however, about the role of TGF-? in cancer drug resistance. In this work, we show a specific activation of the TGF-? pathway in consequence of chemotherapeutic treatment in in vivo and in vitro models of colorectal carcinoma. 5-Fluorouracil (5FU) was able to stimulate the activation of SMAD3 and the transcription of specific genes such as ACVRL1, FN1 and TGFB1. On the other hand, the specific inhibition of TGF-?RI was able to repress the 5FU-induced genes transcription and to restore the sensitivity of chemoresistant cells to the toxic action of the drug, by decreasing the expression of BCL2L1 and ID1 genes. The role of the TGF-? molecule in the chemoresistant colon carcinoma cells' response to 5FU was further demonstrated by conditioned medium (CM) experiments: CM from 5FU-treated chemoresistant cells was able to protect chemosensitive cells against the toxic action of 5FU. In conclusion, these findings showed the pivotal role of TGF-? pathway in colon cancer mechanisms of drug resistance suggesting new possible approaches in diagnosis and treatment of colon cancer patients. äThe TGF-? pathway is activated by 5-fluorouracil treatment in drug res(epmc).pdf DeepDyve Pubget Overpricing