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10.1038/oncsis.2016.55 http://scihub22266oqcxt.onion/10.1038/oncsis.2016.55 C5007829!5007829!27526108     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogenesis 2016 ; 5 (8): e254- Nephropedia Template TP {{tp|p=27526108|t=2016. FLASH protects ZEB1 from degradation and supports cancer cells epithelial-to-mesenchymal transition |pdf=|usr=}}{{27526108}} gab.com Text FLASH protects ZEB1 from degradation and supports cancer cells epithelial-to-mesenchymal transition JO: Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=27526108 #FOAvip Cancer metastasis remains a significant challenge and the leading cause of cancer-associated deaths. It is postulated that during metastasis cells undergo epithelial-to-mesenchymal transition (EMT), a process characterized by loss of cell?cell contacts and increased migratory and invasive potential. ZEB1 is one the most prominent transcriptional repressors of genes associated with EMT. We identified caspase-8-associated protein 2 (CASP8AP2 or FLASH) as a novel posttranscriptional regulator of ZEB1. Here we demonstrate that FLASH protects ZEB1 from proteasomal degradation brought by the action of the ubiquitin ligases SIAH1 and F-box protein FBXO45. As a result, loss of FLASH rapidly destabilized ZEB1 and reversed EMT cellular characteristics. Importantly, loss of FLASH blocked transforming growth factor-?-induced EMT and enhanced sensitivity to chemotherapy. Thus, we propose that FLASH?ZEB1 interplay may be a protective mechanism against ZEB1 degradation in cells undergoing EMT and may be an efficacious target for therapies aimed to block EMT progression. Twit Text FOAVip FLASH protects ZEB1 from degradation and supports cancer cells epithelial-to-mesenchymal transition ????Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=27526108 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27526108 #FOAvip English Wikipedia <ref>{{Cite pmid|27526108}}</ref> FLASH protects ZEB1 from degradation and supports cancer cells epithelial-to-mesenchymal transition #MMPMID27526108 Abshire CF; Carroll JL; Dragoi AM Oncogenesis 2016[Aug]; 5 (8): e254- PMID27526108show ga Cancer metastasis remains a significant challenge and the leading cause of cancer-associated deaths. It is postulated that during metastasis cells undergo epithelial-to-mesenchymal transition (EMT), a process characterized by loss of cell?cell contacts and increased migratory and invasive potential. ZEB1 is one the most prominent transcriptional repressors of genes associated with EMT. We identified caspase-8-associated protein 2 (CASP8AP2 or FLASH) as a novel posttranscriptional regulator of ZEB1. Here we demonstrate that FLASH protects ZEB1 from proteasomal degradation brought by the action of the ubiquitin ligases SIAH1 and F-box protein FBXO45. As a result, loss of FLASH rapidly destabilized ZEB1 and reversed EMT cellular characteristics. Importantly, loss of FLASH blocked transforming growth factor-?-induced EMT and enhanced sensitivity to chemotherapy. Thus, we propose that FLASH?ZEB1 interplay may be a protective mechanism against ZEB1 degradation in cells undergoing EMT and may be an efficacious target for therapies aimed to block EMT progression. äFLASH protects ZEB1 from degradation and supports cancer cells epithe(epmc).pdf DeepDyve Pubget Overpricing