Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s12885-016-2730-2 http://scihub22266oqcxt.onion/10.1186/s12885-016-2730-2 C5007821!5007821!27581969     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27581969&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27581969.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Cancer 2016 ; 16 (1): ä Nephropedia Template TP {{tp|p=27581969|t=2016. Anti-cancer effect of pristimerin by inhibition of HIF-1? involves the SPHK-1 pathway in hypoxic prostate cancer cells |pdf=|usr=}}{{27581969}} gab.com Text Anti-cancer effect of pristimerin by inhibition of HIF-1 involves the SPHK-1 pathway in hypoxic prostate cancer cells JO: BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27581969 #FOAvip Background: Hypoxia is a typical character of locally advanced solid tumours. The transcription factor hypoxia-inducible factor 1? (HIF-1?) is the main regulator under the hypoxic environment. HIF-1? regulates various genes to enhance tumour progression, angiogenesis, and metastasis. Sphingosine kinase 1 (SPHK-1) is a modulator of HIF-1?. Methods: To investigate the molecular mechanisms of pristimerin in association with SPHK-1 pathways in hypoxic PC-3 cancer cells. Vascular endothelial growth factor (VEGF) production, cell cycles, and SPHK-1 activity were measured, and western blotting, an MTT assay, and an RNA interference assay were performed. Results: Pristimerin inhibited HIF-1? accumulation in a concentration- and-time-dependent manner in hypoxic PC-3 cells. Pristimerin suppressed the expression of HIF-1? by inhibiting SPHK-1. Moreover, inhibiting SPHK-1 with a sphingosine kinase inhibitor enhanced the suppression of HIF-1?, phosphorylation AKT, and glycogen synthase kinase-3? (GSK-3?) by pristimerin under hypoxia. Furthermore, a reactive oxygen species (ROS) scavenger enhanced the inhibition of HIF-1? and SPHK-1 by pristimerin. Conclusion: Taken together, these findings suggest that pristimerin can exert an anti-cancer activity by inhibiting HIF-1? through the SPHK-1 pathway. Electronic supplementary material: The online version of this article (doi:10.1186/s12885-016-2730-2) contains supplementary material, which is available to authorized users. Twit Text FOAVip Anti-cancer effect of pristimerin by inhibition of HIF-1 involves the SPHK-1 pathway in hypoxic prostate cancer cells ????BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27581969 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27581969 #FOAvip English Wikipedia <ref>{{Cite pmid|27581969}}</ref> Anti-cancer effect of pristimerin by inhibition of HIF-1? involves the SPHK-1 pathway in hypoxic prostate cancer cells #MMPMID27581969 Lee SO; Kim JS; Lee MS; Lee HJ BMC Cancer 2016[]; 16 (1): ä PMID27581969show ga Background: Hypoxia is a typical character of locally advanced solid tumours. The transcription factor hypoxia-inducible factor 1? (HIF-1?) is the main regulator under the hypoxic environment. HIF-1? regulates various genes to enhance tumour progression, angiogenesis, and metastasis. Sphingosine kinase 1 (SPHK-1) is a modulator of HIF-1?. Methods: To investigate the molecular mechanisms of pristimerin in association with SPHK-1 pathways in hypoxic PC-3 cancer cells. Vascular endothelial growth factor (VEGF) production, cell cycles, and SPHK-1 activity were measured, and western blotting, an MTT assay, and an RNA interference assay were performed. Results: Pristimerin inhibited HIF-1? accumulation in a concentration- and-time-dependent manner in hypoxic PC-3 cells. Pristimerin suppressed the expression of HIF-1? by inhibiting SPHK-1. Moreover, inhibiting SPHK-1 with a sphingosine kinase inhibitor enhanced the suppression of HIF-1?, phosphorylation AKT, and glycogen synthase kinase-3? (GSK-3?) by pristimerin under hypoxia. Furthermore, a reactive oxygen species (ROS) scavenger enhanced the inhibition of HIF-1? and SPHK-1 by pristimerin. Conclusion: Taken together, these findings suggest that pristimerin can exert an anti-cancer activity by inhibiting HIF-1? through the SPHK-1 pathway. Electronic supplementary material: The online version of this article (doi:10.1186/s12885-016-2730-2) contains supplementary material, which is available to authorized users. äAnti-cancer effect of pristimerin by inhibition of HIF-1? involves the(epmc).pdf DeepDyve Pubget Overpricing