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10.12688/f1000research.9207.1 http://scihub22266oqcxt.onion/10.12688/f1000research.9207.1 C5007757!5007757!27635236     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27635236&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       F1000Res 2016 ; 5 (ä): ä Nephropedia Template TP {{tp|p=27635236|t=2016. mTOR inhibitors in cancer therapy |pdf=|usr=}}{{27635236}} gab.com Text mTOR inhibitors in cancer therapy JO: F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=27635236 #FOAvip The mammalian target of rapamycin, mTOR, plays key roles in cell growth and proliferation, acting at the catalytic subunit of two protein kinase complexes: mTOR complexes 1 and 2 (mTORC1/2). mTORC1 signaling is switched on by several oncogenic signaling pathways and is accordingly hyperactive in the majority of cancers. Inhibiting mTORC1 signaling has therefore attracted great attention as an anti-cancer therapy. However, progress in using inhibitors of mTOR signaling as therapeutic agents in oncology has been limited by a number of factors, including the fact that the classic mTOR inhibitor, rapamycin, inhibits only some of the effects of mTOR; the existence of several feedback loops; and the crucial importance of mTOR in normal physiology. Twit Text FOAVip mTOR inhibitors in cancer therapy ????F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=27635236 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27635236 #FOAvip English Wikipedia <ref>{{Cite pmid|27635236}}</ref> mTOR inhibitors in cancer therapy #MMPMID27635236 Xie J; Wang X; Proud CG F1000Res 2016[]; 5 (ä): ä PMID27635236show ga The mammalian target of rapamycin, mTOR, plays key roles in cell growth and proliferation, acting at the catalytic subunit of two protein kinase complexes: mTOR complexes 1 and 2 (mTORC1/2). mTORC1 signaling is switched on by several oncogenic signaling pathways and is accordingly hyperactive in the majority of cancers. Inhibiting mTORC1 signaling has therefore attracted great attention as an anti-cancer therapy. However, progress in using inhibitors of mTOR signaling as therapeutic agents in oncology has been limited by a number of factors, including the fact that the classic mTOR inhibitor, rapamycin, inhibits only some of the effects of mTOR; the existence of several feedback loops; and the crucial importance of mTOR in normal physiology. ämTOR inhibitors in cancer therapy (epmc).pdf DeepDyve Pubget Overpricing