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10.15252/embr.201642463 http://scihub22266oqcxt.onion/10.15252/embr.201642463 C5007574!5007574 !27418314     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27418314 &cmd=llinks): Failed to open stream: HTTP request failed! 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Gut microbiota directs PPAR?-driven reprogramming of the liver circadian clock by nutritional challenge |pdf=|usr=}}{{27418314 }} gab.com Text Gut microbiota directs PPAR -driven reprogramming of the liver circadian clock by nutritional challenge JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=27418314 #FOAvip The liver circadian clock is reprogrammed by nutritional challenge through the rewiring of specific transcriptional pathways. As the gut microbiota is tightly connected to host metabolism, whose coordination is governed by the circadian clock, we explored whether gut microbes influence circadian homeostasis and how they distally control the peripheral clock in the liver. Using fecal transplant procedures we reveal that, in response to high-fat diet, the gut microbiota drives PPAR?-mediated activation of newly oscillatory transcriptional programs in the liver. Moreover, antibiotics treatment prevents PPAR?-driven transcription in the liver, underscoring the essential role of gut microbes in clock reprogramming and hepatic circadian homeostasis. Thus, a specific molecular signature characterizes the influence of the gut microbiome in the liver, leading to the transcriptional rewiring of hepatic metabolism. Twit Text FOAVip Gut microbiota directs PPAR -driven reprogramming of the liver circadian clock by nutritional challenge ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=27418314 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27418314 #FOAvip English Wikipedia <ref>{{Cite pmid|27418314 }}</ref> Gut microbiota directs PPAR?-driven reprogramming of the liver circadian clock by nutritional challenge #MMPMID27418314 Murakami M ; Tognini P ; Liu Y ; Eckel-Mahan KL ; Baldi P ; Sassone-Corsi P EMBO Rep 2016[Sep]; 17 (9 ): 1292-303 PMID27418314 show ga The liver circadian clock is reprogrammed by nutritional challenge through the rewiring of specific transcriptional pathways. As the gut microbiota is tightly connected to host metabolism, whose coordination is governed by the circadian clock, we explored whether gut microbes influence circadian homeostasis and how they distally control the peripheral clock in the liver. Using fecal transplant procedures we reveal that, in response to high-fat diet, the gut microbiota drives PPAR?-mediated activation of newly oscillatory transcriptional programs in the liver. Moreover, antibiotics treatment prevents PPAR?-driven transcription in the liver, underscoring the essential role of gut microbes in clock reprogramming and hepatic circadian homeostasis. Thus, a specific molecular signature characterizes the influence of the gut microbiome in the liver, leading to the transcriptional rewiring of hepatic metabolism. |*Circadian Clocks/drug effects/genetics [MESH] |*Diet, High-Fat [MESH] |*Gastrointestinal Microbiome/drug effects [MESH] |Animals [MESH] |Anti-Bacterial Agents/pharmacology [MESH] |Blood Glucose [MESH] |Circadian Rhythm [MESH] |Cluster Analysis [MESH] |Energy Metabolism/genetics [MESH] |Fecal Microbiota Transplantation [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Liver/*metabolism [MESH] |Male [MESH] |Mice [MESH] |PPAR gamma/*metabolism [MESH]Gut microbiota directs PPAR?-driven reprogramming of the liver circadi(epmc).pdf DeepDyve Pubget Overpricing