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10.15252/embr.201541852 http://scihub22266oqcxt.onion/10.15252/embr.201541852 C5007572!5007572!27466323     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2016 ; 17 (9): 1343-59 Nephropedia Template TP {{tp|p=27466323|t=2016. Dynamic cohesin?mediated chromatin architecture controls epithelial?mesenchymal plasticity in cancer |pdf=|usr=}}{{27466323}} gab.com Text Dynamic cohesin mediated chromatin architecture controls epithelial mesenchymal plasticity in cancer JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=27466323 #FOAvip Epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET) are important interconnected events in tumorigenesis controlled by complex genetic networks. However, the cues that activate EMT?initiating factors and the mechanisms that reversibly connect EMT/MET are not well understood. Here, we show that cohesin?mediated chromatin organization coordinates EMT/MET by regulating mesenchymal genes. We report that RAD21, a subunit of the cohesin complex, is expressed in epithelial breast cancer cells, whereas its expression is decreased in mesenchymal cancer. Depletion of RAD21 in epithelial cancer cells causes transcriptional activation of TGFB1 and ITGA5, inducing EMT. Reduced binding of RAD21 changes intrachromosomal chromatin interactions within the TGFB1 and ITGA5 loci, creating an active transcriptional environment. Similarly, stem cell?like cancer cells also show an open chromatin structure at both genes, which correlates with high expression levels and mesenchymal fate characteristics. Conversely, overexpression of RAD21 in mesenchymal cancer cells induces MET?specific expression patterns. These findings indicate that dynamic cohesin?mediated chromatin structures are responsible for the initiation and regulation of essential EMT?related cell fate changes in cancer. Twit Text FOAVip Dynamic cohesin mediated chromatin architecture controls epithelial mesenchymal plasticity in cancer ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=27466323 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27466323 #FOAvip English Wikipedia <ref>{{Cite pmid|27466323}}</ref> Dynamic cohesin?mediated chromatin architecture controls epithelial?mesenchymal plasticity in cancer #MMPMID27466323 Yun J; Song S; Kim H; Han S; Yi EC; Kim T EMBO Rep 2016[Sep]; 17 (9): 1343-59 PMID27466323show ga Epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET) are important interconnected events in tumorigenesis controlled by complex genetic networks. However, the cues that activate EMT?initiating factors and the mechanisms that reversibly connect EMT/MET are not well understood. Here, we show that cohesin?mediated chromatin organization coordinates EMT/MET by regulating mesenchymal genes. We report that RAD21, a subunit of the cohesin complex, is expressed in epithelial breast cancer cells, whereas its expression is decreased in mesenchymal cancer. Depletion of RAD21 in epithelial cancer cells causes transcriptional activation of TGFB1 and ITGA5, inducing EMT. Reduced binding of RAD21 changes intrachromosomal chromatin interactions within the TGFB1 and ITGA5 loci, creating an active transcriptional environment. Similarly, stem cell?like cancer cells also show an open chromatin structure at both genes, which correlates with high expression levels and mesenchymal fate characteristics. Conversely, overexpression of RAD21 in mesenchymal cancer cells induces MET?specific expression patterns. These findings indicate that dynamic cohesin?mediated chromatin structures are responsible for the initiation and regulation of essential EMT?related cell fate changes in cancer. äDynamic cohesin?mediated chromatin architecture controls epithelial?me(epmc).pdf DeepDyve Pubget Overpricing