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10.15252/embr.201642282 http://scihub22266oqcxt.onion/10.15252/embr.201642282 C5007561!5007561!27432285     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2016 ; 17 (9): 1281-91 Nephropedia Template TP {{tp|p=27432285|t=2016. Strain competition restricts colonization of an enteric pathogen and prevents colitis |pdf=|usr=}}{{27432285}} gab.com Text Strain competition restricts colonization of an enteric pathogen and prevents colitis JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=27432285 #FOAvip The microbiota is a major source of protection against intestinal pathogens; however, the specific bacteria and underlying mechanisms involved are not well understood. As a model of this interaction, we sought to determine whether colonization of the murine host with symbiotic non?toxigenic Bacteroides fragilis could limit acquisition of pathogenic enterotoxigenic B. fragilis. We observed strain?specific competition with toxigenic B. fragilis, dependent upon type VI secretion, identifying an effector?immunity pair that confers pathogen exclusion. Resistance against host acquisition of a second non?toxigenic strain was also uncovered, revealing a broader function of type VI secretion systems in determining microbiota composition. The competitive exclusion of enterotoxigenic B. fragilis by a non?toxigenic strain limited toxin exposure and protected the host against intestinal inflammatory disease. Our studies demonstrate a novel role of type VI secretion systems in colonization resistance against a pathogen. This understanding of bacterial competition may be utilized to define a molecularly targeted probiotic strategy. Twit Text FOAVip Strain competition restricts colonization of an enteric pathogen and prevents colitis ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=27432285 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27432285 #FOAvip English Wikipedia <ref>{{Cite pmid|27432285}}</ref> Strain competition restricts colonization of an enteric pathogen and prevents colitis #MMPMID27432285 Hecht AL; Casterline BW; Earley ZM; Goo YA; Goodlett DR; Bubeck Wardenburg J EMBO Rep 2016[Sep]; 17 (9): 1281-91 PMID27432285show ga The microbiota is a major source of protection against intestinal pathogens; however, the specific bacteria and underlying mechanisms involved are not well understood. As a model of this interaction, we sought to determine whether colonization of the murine host with symbiotic non?toxigenic Bacteroides fragilis could limit acquisition of pathogenic enterotoxigenic B. fragilis. We observed strain?specific competition with toxigenic B. fragilis, dependent upon type VI secretion, identifying an effector?immunity pair that confers pathogen exclusion. Resistance against host acquisition of a second non?toxigenic strain was also uncovered, revealing a broader function of type VI secretion systems in determining microbiota composition. The competitive exclusion of enterotoxigenic B. fragilis by a non?toxigenic strain limited toxin exposure and protected the host against intestinal inflammatory disease. Our studies demonstrate a novel role of type VI secretion systems in colonization resistance against a pathogen. This understanding of bacterial competition may be utilized to define a molecularly targeted probiotic strategy. äStrain competition restricts colonization of an enteric pathogen and p(epmc).pdf DeepDyve Pubget Overpricing