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10.15252/embj.201694300 http://scihub22266oqcxt.onion/10.15252/embj.201694300 C5007551!5007551!27307491     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2016 ; 35 (17): 1868-84 Nephropedia Template TP {{tp|p=27307491|t=2016. SPATA2 links CYLD to the TNF?? receptor signaling complex and modulates the receptor signaling outcomes |pdf=|usr=}}{{27307491}} gab.com Text SPATA2 links CYLD to the TNF receptor signaling complex and modulates the receptor signaling outcomes JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=27307491 #FOAvip TNF?? is a key regulator of innate immune and proinflammatory responses. However, the composition of the TNF?? receptor?associated signaling complexes (TNF?RSC) and the architecture of the downstream signaling networks are incompletely understood. We employed quantitative mass spectrometry to demonstrate that TNF?? stimulation induces widespread protein phosphorylation and that the scope of phosphorylation expands in a temporal manner. TNF?? stimulation also induces rapid ubiquitylation of components of the TNF?RSC. Temporal analysis of the TNF?RSC composition identified SPATA2 as a novel component of the TNF?RSC. The predicted PUB domain in the N?terminus of SPATA2 interacts with the USP domain of CYLD, whereas the C?terminus of SPATA2 interacts with HOIP. SPATA2 is required for recruitment of CYLD to the TNF?RSC. Downregulation of SPATA2 augments transcriptional activation of NF??B and inhibits TNF???induced necroptosis, pointing to an important function of SPATA2 in modulating the outcomes of TNF?? signaling. Taken together, our study draws a detailed map of TNF?? signaling, identifies SPATA2 as a novel component of TNF?? signaling, and provides a rich resource for further functional investigations. Twit Text FOAVip SPATA2 links CYLD to the TNF receptor signaling complex and modulates the receptor signaling outcomes ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=27307491 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27307491 #FOAvip English Wikipedia <ref>{{Cite pmid|27307491}}</ref> SPATA2 links CYLD to the TNF?? receptor signaling complex and modulates the receptor signaling outcomes #MMPMID27307491 Wagner SA; Satpathy S; Beli P; Choudhary C EMBO J 2016[Sep]; 35 (17): 1868-84 PMID27307491show ga TNF?? is a key regulator of innate immune and proinflammatory responses. However, the composition of the TNF?? receptor?associated signaling complexes (TNF?RSC) and the architecture of the downstream signaling networks are incompletely understood. We employed quantitative mass spectrometry to demonstrate that TNF?? stimulation induces widespread protein phosphorylation and that the scope of phosphorylation expands in a temporal manner. TNF?? stimulation also induces rapid ubiquitylation of components of the TNF?RSC. Temporal analysis of the TNF?RSC composition identified SPATA2 as a novel component of the TNF?RSC. The predicted PUB domain in the N?terminus of SPATA2 interacts with the USP domain of CYLD, whereas the C?terminus of SPATA2 interacts with HOIP. SPATA2 is required for recruitment of CYLD to the TNF?RSC. Downregulation of SPATA2 augments transcriptional activation of NF??B and inhibits TNF???induced necroptosis, pointing to an important function of SPATA2 in modulating the outcomes of TNF?? signaling. Taken together, our study draws a detailed map of TNF?? signaling, identifies SPATA2 as a novel component of TNF?? signaling, and provides a rich resource for further functional investigations. äSPATA2 links CYLD to the TNF?? receptor signaling complex and modulate(epmc).pdf DeepDyve Pubget Overpricing