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10.15252/embj.201695134

http://scihub22266oqcxt.onion/10.15252/embj.201695134
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C5007549!5007549!27440401
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suck abstract from ncbi

pmid27440401      EMBO+J 2016 ; 35 (17): 1845-7
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  • Autophagosome?lysosome fusion: PIs to the rescue #MMPMID27440401
  • Li L; Zhong Q
  • EMBO J 2016[Sep]; 35 (17): 1845-7 PMID27440401show ga
  • Phosphoinositides (PIs), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PIs play a critical role in autophagy, but only PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016) identified INPP5E, an inositol polyphosphate 5?phosphatase, as a novel regulator of autophagy. INPP5E controls the level of PI(3,5)P2 at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome?lysosome fusion.
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