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Autophagosome?lysosome fusion: PIs to the rescue #MMPMID27440401
Li L; Zhong Q
EMBO J 2016[Sep]; 35 (17): 1845-7 PMID27440401show ga
Phosphoinositides (PIs), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PIs play a critical role in autophagy, but only PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016) identified INPP5E, an inositol polyphosphate 5?phosphatase, as a novel regulator of autophagy. INPP5E controls the level of PI(3,5)P2 at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome?lysosome fusion.