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10.1038/srep32415 http://scihub22266oqcxt.onion/10.1038/srep32415 C5007537!5007537 !27581189     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27581189 &cmd=llinks): Failed to open stream: HTTP request failed! 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Novel Foxp3(-) IL-10(-) Regulatory T-cells Induced by B-Cells Alleviate Intestinal Inflammation in Vivo |pdf=|usr=}}{{27581189 }} gab.com Text Novel Foxp3(-) IL-10(-) Regulatory T-cells Induced by B-Cells Alleviate Intestinal Inflammation in Vivo JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27581189 #FOAvip Recent studies have revealed various Foxp3(-) regulatory T (Treg) cell subsets effectively protect mice from colitis. In the present study, we demonstrated that B cells induced a particular subset of regulatory T (Treg-of-B) cells, expressing programmed cell death 1 (PD-1), inducible costimulator (ICOS), lymphocyte-activation gene 3 (LAG3), glucocorticoid-induced tumor necrosis factor receptor (GITR), and OX-40, did not express Foxp3. Treg-of-B cells produced abundant levels of IL-10 and low levels of IL-4 and TGF-?. Adoptive transfer of Treg-of-B cells protected mice from CD4(+)CD45RB(hi) T-cell-induced colitis, including infiltration of leukocytes, depletion of goblet cells, epithelial hyperplasia, and inhibition of Th1 and Th17 cytokines. These features were similar to IL-10-producing type 1 regulatory T (Tr1) cells; however, IL-10-deficient Treg-of-B cells maintained their suppressive function in vitro as well as in vivo, while the regulation of Tr1 cells depended on IL-10. In conclusion, Treg-of-B cells protected against experimental colitis through an IL-10-independent mechanism. We reported a novel subpopulation of regulatory T cells was different from conventional Foxp3(+) Treg and IL-10-producing Tr1 cells. Twit Text FOAVip Novel Foxp3(-) IL-10(-) Regulatory T-cells Induced by B-Cells Alleviate Intestinal Inflammation in Vivo ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27581189 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27581189 #FOAvip English Wikipedia <ref>{{Cite pmid|27581189 }}</ref> Novel Foxp3(-) IL-10(-) Regulatory T-cells Induced by B-Cells Alleviate Intestinal Inflammation in Vivo #MMPMID27581189 Shao TY ; Hsu LH ; Chien CH ; Chiang BL Sci Rep 2016[Sep]; 6 (ä): 32415 PMID27581189 show ga Recent studies have revealed various Foxp3(-) regulatory T (Treg) cell subsets effectively protect mice from colitis. In the present study, we demonstrated that B cells induced a particular subset of regulatory T (Treg-of-B) cells, expressing programmed cell death 1 (PD-1), inducible costimulator (ICOS), lymphocyte-activation gene 3 (LAG3), glucocorticoid-induced tumor necrosis factor receptor (GITR), and OX-40, did not express Foxp3. Treg-of-B cells produced abundant levels of IL-10 and low levels of IL-4 and TGF-?. Adoptive transfer of Treg-of-B cells protected mice from CD4(+)CD45RB(hi) T-cell-induced colitis, including infiltration of leukocytes, depletion of goblet cells, epithelial hyperplasia, and inhibition of Th1 and Th17 cytokines. These features were similar to IL-10-producing type 1 regulatory T (Tr1) cells; however, IL-10-deficient Treg-of-B cells maintained their suppressive function in vitro as well as in vivo, while the regulation of Tr1 cells depended on IL-10. In conclusion, Treg-of-B cells protected against experimental colitis through an IL-10-independent mechanism. We reported a novel subpopulation of regulatory T cells was different from conventional Foxp3(+) Treg and IL-10-producing Tr1 cells. |Adoptive Transfer [MESH] |Animals [MESH] |Antigens, CD/genetics/immunology [MESH] |B-Lymphocytes/*immunology/pathology [MESH] |Cell Communication/immunology [MESH] |Colitis/genetics/*immunology/pathology/prevention & control [MESH] |Disease Models, Animal [MESH] |Forkhead Transcription Factors/deficiency/genetics/*immunology [MESH] |Gene Expression Regulation [MESH] |Glucocorticoid-Induced TNFR-Related Protein/genetics/immunology [MESH] |Goblet Cells/immunology/pathology [MESH] |Inducible T-Cell Co-Stimulator Protein/genetics/immunology [MESH] |Interleukin-10/deficiency/genetics/*immunology [MESH] |Interleukin-4/genetics/immunology [MESH] |Intestines/immunology/pathology [MESH] |Lymphocyte Activation Gene 3 Protein [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, SCID [MESH] |Programmed Cell Death 1 Receptor/genetics/immunology [MESH] |Receptors, OX40/genetics/immunology [MESH] |Severity of Illness Index [MESH] |Signal Transduction [MESH] |T-Lymphocytes, Regulatory/*immunology/pathology/transplantation [MESH] |Th1 Cells/immunology/pathology [MESH] |Th17 Cells/immunology/pathology [MESH]Novel Foxp3(-) IL-10(-) Regulatory T-cells Induced by B-Cells Alleviat(epmc).pdf DeepDyve Pubget Overpricing