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10.1038/srep32087 http://scihub22266oqcxt.onion/10.1038/srep32087 C5007516!5007516 !27580845     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27580845 &cmd=llinks): Failed to open stream: HTTP request failed! 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Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models |pdf=|usr=}}{{27580845 }} gab.com Text Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27580845 #FOAvip Podocyte injury and the appearance of proteinuria are features of minimal-change disease (MCD). Cyclosporin A (CsA) and tacrolimus (FK506) has been reported to reduce proteinuria in patients with nephrotic syndrome, but mechanisms remain unknown. We, therefore, investigated the protective mechanisms of CsA and FK506 on proteinuria in a rat model of MCD induced by puromycin aminonucleoside (PAN) and in vitro cultured mouse podocytes. Our results showed that CsA and FK506 treatment decreased proteinuria via a mechanism associated to a reduction in the foot-process fusion and desmin, and a recovery of synaptopodin and podocin. In PAN-treated mouse podocytes, pre-incubation with CsA and FK506 restored the distribution of the actin cytoskeleton, increased the expression of synaptopodin and podocin, improved podocyte viability, and reduced the migrating activities of podocytes. Treatment with CsA and FK506 also inhibited PAN-induced podocytes apoptosis, which was associated with the induction of Bcl-xL and inhibition of Bax, cleaved caspase 3, and cleaved PARP expression. Further studies revealed that CsA and FK506 inhibited PAN-induced p38 and JNK signaling, thereby protecting podocytes from PAN-induced injury. In conclusion, CsA and FK506 inhibit proteinuria by protecting against PAN-induced podocyte injury, which may be associated with inhibition of the MAPK signaling pathway. Twit Text FOAVip Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27580845 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27580845 #FOAvip English Wikipedia <ref>{{Cite pmid|27580845 }}</ref> Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models #MMPMID27580845 Shen X ; Jiang H ; Ying M ; Xie Z ; Li X ; Wang H ; Zhao J ; Lin C ; Wang Y ; Feng S ; Shen J ; Weng C ; Lin W ; Wang H ; Zhou Q ; Bi Y ; Li M ; Wang L ; Zhu T ; Huang X ; Lan HY ; Zhou J ; Chen J Sci Rep 2016[Sep]; 6 (ä): 32087 PMID27580845 show ga Podocyte injury and the appearance of proteinuria are features of minimal-change disease (MCD). Cyclosporin A (CsA) and tacrolimus (FK506) has been reported to reduce proteinuria in patients with nephrotic syndrome, but mechanisms remain unknown. We, therefore, investigated the protective mechanisms of CsA and FK506 on proteinuria in a rat model of MCD induced by puromycin aminonucleoside (PAN) and in vitro cultured mouse podocytes. Our results showed that CsA and FK506 treatment decreased proteinuria via a mechanism associated to a reduction in the foot-process fusion and desmin, and a recovery of synaptopodin and podocin. In PAN-treated mouse podocytes, pre-incubation with CsA and FK506 restored the distribution of the actin cytoskeleton, increased the expression of synaptopodin and podocin, improved podocyte viability, and reduced the migrating activities of podocytes. Treatment with CsA and FK506 also inhibited PAN-induced podocytes apoptosis, which was associated with the induction of Bcl-xL and inhibition of Bax, cleaved caspase 3, and cleaved PARP expression. Further studies revealed that CsA and FK506 inhibited PAN-induced p38 and JNK signaling, thereby protecting podocytes from PAN-induced injury. In conclusion, CsA and FK506 inhibit proteinuria by protecting against PAN-induced podocyte injury, which may be associated with inhibition of the MAPK signaling pathway. |*Calcineurin Inhibitors [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Cell Line [MESH] |Cyclosporine/*administration & dosage [MESH] |MAP Kinase Signaling System/drug effects [MESH] |Male [MESH] |Mice [MESH] |Nephrosis, Lipoid/chemically induced/*complications/pathology [MESH] |Podocytes/*drug effects/metabolism/ultrastructure [MESH] |Proteinuria/complications/*metabolism/pathology/*prevention & control [MESH] |Puromycin Aminonucleoside/administration & dosage [MESH] |Rats, Sprague-Dawley [MESH]Calcineurin inhibitors cyclosporin A and tacrolimus protect against po(epmc).pdf DeepDyve Pubget Overpricing