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10.1038/srep32506 http://scihub22266oqcxt.onion/10.1038/srep32506 C5007471!5007471 !27581921     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27581921 &cmd=llinks): Failed to open stream: HTTP request failed! 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New concept for the prevention and treatment of metastatic lymph nodes using chemotherapy administered via the lymphatic network |pdf=|usr=}}{{27581921 }} gab.com Text New concept for the prevention and treatment of metastatic lymph nodes using chemotherapy administered via the lymphatic network JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27581921 #FOAvip Intravenous chemotherapy has poor access to metastatic lymph nodes (LNs) and is limited by short-lived drug concentrations. Here, we describe the administration of chemotherapy via the lymphatic network as a new concept for the prevention and treatment of metastatic LNs. A metastatic LN can be treated by the injection of drugs into an upstream LN, either the sentinel LN (SLN) or another upstream LN. In a mouse model, tumor cells were inoculated into the subiliac LN (SiLN) to induce metastasis to the proper axillary LN (PALN). Two routes were used for drug delivery to the PALN, namely from the SiLN and from the accessory axillary LN (AALN). We found that tumor masses were formed in lymphatic vessels between the SiLN and PALN. The flow of fluorescent solution injected into the SiLN towards the PALN decreased with tumor mass formation. Delivery from the AALN (free of metastatic tumor cells) to the PALN was identified as an alternative route. Intranodal injection can deliver high concentrations of drugs to secondary metastatic LNs. The study advocates a new concept for the prevention and treatment of metastatic lymph nodes whereby drugs injected into upstream lymph nodes can reach metastatic lymph nodes via the lymphatic network. Twit Text FOAVip New concept for the prevention and treatment of metastatic lymph nodes using chemotherapy administered via the lymphatic network ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27581921 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27581921 #FOAvip English Wikipedia <ref>{{Cite pmid|27581921 }}</ref> New concept for the prevention and treatment of metastatic lymph nodes using chemotherapy administered via the lymphatic network #MMPMID27581921 Kodama T ; Matsuki D ; Tada A ; Takeda K ; Mori S Sci Rep 2016[Sep]; 6 (ä): 32506 PMID27581921 show ga Intravenous chemotherapy has poor access to metastatic lymph nodes (LNs) and is limited by short-lived drug concentrations. Here, we describe the administration of chemotherapy via the lymphatic network as a new concept for the prevention and treatment of metastatic LNs. A metastatic LN can be treated by the injection of drugs into an upstream LN, either the sentinel LN (SLN) or another upstream LN. In a mouse model, tumor cells were inoculated into the subiliac LN (SiLN) to induce metastasis to the proper axillary LN (PALN). Two routes were used for drug delivery to the PALN, namely from the SiLN and from the accessory axillary LN (AALN). We found that tumor masses were formed in lymphatic vessels between the SiLN and PALN. The flow of fluorescent solution injected into the SiLN towards the PALN decreased with tumor mass formation. Delivery from the AALN (free of metastatic tumor cells) to the PALN was identified as an alternative route. Intranodal injection can deliver high concentrations of drugs to secondary metastatic LNs. The study advocates a new concept for the prevention and treatment of metastatic lymph nodes whereby drugs injected into upstream lymph nodes can reach metastatic lymph nodes via the lymphatic network. |Animals [MESH] |Antineoplastic Agents/pharmacokinetics/*pharmacology [MESH] |Carbon/administration & dosage [MESH] |Disease Models, Animal [MESH] |Gene Expression [MESH] |Genes, Reporter [MESH] |Green Fluorescent Proteins/genetics/metabolism [MESH] |Histiocytoma, Malignant Fibrous/*drug therapy/metabolism/pathology [MESH] |Injections, Intralymphatic [MESH] |Luciferases/genetics/metabolism [MESH] |Lymph Nodes/*drug effects/metabolism/pathology [MESH] |Lymphatic Metastasis [MESH] |Lymphatic Vessels/*drug effects/metabolism/pathology [MESH] |Mice [MESH]New concept for the prevention and treatment of metastatic lymph nodes(epmc).pdf DeepDyve Pubget Overpricing