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10.1038/ncomms12656 http://scihub22266oqcxt.onion/10.1038/ncomms12656 C5007377!5007377!27557800     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27557800|t=2016. A strategy to discover new organizers identifies a putative heart organizer |pdf=|usr=}}{{27557800}} gab.com Text A strategy to discover new organizers identifies a putative heart organizer JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27557800 #FOAvip Organizers are regions of the embryo that can both induce new fates and impart pattern on other regions. So far, surprisingly few organizers have been discovered, considering the number of patterned tissue types generated during development. This may be because their discovery has relied on transplantation and ablation experiments. Here we describe a new approach, using chick embryos, to discover organizers based on a common gene expression signature, and use it to uncover the anterior intestinal portal (AIP) endoderm as a putative heart organizer. We show that the AIP can induce cardiac identity from non-cardiac mesoderm and that it can pattern this by specifying ventricular and suppressing atrial regional identity. We also uncover some of the signals responsible. The method holds promise as a tool to discover other novel organizers acting during development. Twit Text FOAVip A strategy to discover new organizers identifies a putative heart organizer ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27557800 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27557800 #FOAvip English Wikipedia <ref>{{Cite pmid|27557800}}</ref> A strategy to discover new organizers identifies a putative heart organizer #MMPMID27557800 Anderson C; Khan MAF; Wong F; Solovieva T; Oliveira NMM; Baldock RA; Tickle C; Burt DW; Stern CD Nat Commun 2016[]; 7 (ä): ä PMID27557800show ga Organizers are regions of the embryo that can both induce new fates and impart pattern on other regions. So far, surprisingly few organizers have been discovered, considering the number of patterned tissue types generated during development. This may be because their discovery has relied on transplantation and ablation experiments. Here we describe a new approach, using chick embryos, to discover organizers based on a common gene expression signature, and use it to uncover the anterior intestinal portal (AIP) endoderm as a putative heart organizer. We show that the AIP can induce cardiac identity from non-cardiac mesoderm and that it can pattern this by specifying ventricular and suppressing atrial regional identity. We also uncover some of the signals responsible. The method holds promise as a tool to discover other novel organizers acting during development. äA strategy to discover new organizers identifies a putative heart orga(epmc).pdf DeepDyve Pubget Overpricing