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10.1093/femsre/fuw009 http://scihub22266oqcxt.onion/10.1093/femsre/fuw009 C5007280!5007280!27268906     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEMS+Microbiol+Rev 2016 ; 40 (5): 774-94 Nephropedia Template TP {{tp|p=27268906|t=2016. Chemical probes of quorum sensing: from compound development to biological discovery |pdf=|usr=}}{{27268906}} gab.com Text Chemical probes of quorum sensing: from compound development to biological discovery JO: FEMS Microbiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=27268906 #FOAvip Bacteria can utilize chemical signals to coordinate the expression of group-beneficial behaviors in a method of cell?cell communication called quorum sensing (QS). The discovery that QS controls the production of virulence factors and biofilm formation in many common pathogens has driven an explosion of research aimed at both deepening our fundamental understanding of these regulatory networks and developing chemical agents that can attenuate QS signaling. The inherently chemical nature of QS makes studying these pathways with small molecule tools a complementary approach to traditional microbiology techniques. Indeed, chemical tools are beginning to yield new insights into QS regulation and provide novel strategies to inhibit QS. Here, we review the most recent advances in the development of chemical probes of QS systems in Gram-negative bacteria, with an emphasis on the opportunistic pathogen Pseudomonas aeruginosa. We first describe reports of novel small molecule modulators of QS receptors and QS signal synthases. Next, in several case studies, we showcase how chemical tools have been deployed to reveal new knowledge of QS biology and outline lessons for how researchers might best target QS to combat bacterial virulence. To close, we detail the outstanding challenges in the field and suggest strategies to overcome these issues. Twit Text FOAVip Chemical probes of quorum sensing: from compound development to biological discovery ????FEMS Microbiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=27268906 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27268906 #FOAvip English Wikipedia <ref>{{Cite pmid|27268906}}</ref> Chemical probes of quorum sensing: from compound development to biological discovery #MMPMID27268906 Welsh MA; Blackwell HE FEMS Microbiol Rev 2016[Sep]; 40 (5): 774-94 PMID27268906show ga Bacteria can utilize chemical signals to coordinate the expression of group-beneficial behaviors in a method of cell?cell communication called quorum sensing (QS). The discovery that QS controls the production of virulence factors and biofilm formation in many common pathogens has driven an explosion of research aimed at both deepening our fundamental understanding of these regulatory networks and developing chemical agents that can attenuate QS signaling. The inherently chemical nature of QS makes studying these pathways with small molecule tools a complementary approach to traditional microbiology techniques. Indeed, chemical tools are beginning to yield new insights into QS regulation and provide novel strategies to inhibit QS. Here, we review the most recent advances in the development of chemical probes of QS systems in Gram-negative bacteria, with an emphasis on the opportunistic pathogen Pseudomonas aeruginosa. We first describe reports of novel small molecule modulators of QS receptors and QS signal synthases. Next, in several case studies, we showcase how chemical tools have been deployed to reveal new knowledge of QS biology and outline lessons for how researchers might best target QS to combat bacterial virulence. To close, we detail the outstanding challenges in the field and suggest strategies to overcome these issues. äChemical probes of quorum sensing: from compound development to biolog(epmc).pdf DeepDyve Pubget Overpricing