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10.1371/journal.pone.0161570 http://scihub22266oqcxt.onion/10.1371/journal.pone.0161570 C5007012!5007012!27579896     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2016 ; 11 (8): ä Nephropedia Template TP {{tp|p=27579896|t=2016. A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis |pdf=|usr=}}{{27579896}} gab.com Text A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27579896 #FOAvip Recent studies have shown that a large proportion of patients classified as essential thrombocythemia (ET) actually have early primary prefibrotic myelofibrosis (prePMF), which implies an inferior prognosis as compared to patients being diagnosed with so-called genuine or true ET. According to the World Health Organization (WHO) 2008 classification, bone marrow histology is a major component in the distinction between these disease entities. However, the differential diagnosis between them may be challenging and several studies have not been able to distinguish between them. Most lately, it has been argued that simple blood tests, including the leukocyte count and plasma lactate dehydrogenase (LDH) may be useful tools to separate genuine ET from prePMF, the latter disease entity more often being featured by anemia, leukocytosis and elevated LDH. Whole blood gene expression profiling was performed in 17 and 9 patients diagnosed with ET and PMF, respectively. Using elevated LDH obtained at the time of diagnosis as a marker of prePMF, a 7-gene signature was identified which correctly predicted the prePMF group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8, which are genes known to be involved in inflammation, cell adhesion, differentiation and proliferation. Evaluation of bone marrow biopsies and the 7-gene signature showed a concordance rate of 71%, 79%, 62%, and 38%. Our 7-gene signature may be a useful tool to differentiate between genuine ET and prePMF but needs to be validated in a larger cohort of ?ET? patients. Twit Text FOAVip A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27579896 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27579896 #FOAvip English Wikipedia <ref>{{Cite pmid|27579896}}</ref> A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis #MMPMID27579896 Skov V; Burton M; Thomassen M; Stauffer Larsen T; Riley CH; Brinch Madelung A; Kjær L; Bondo H; Stamp I; Ehinger M; Dahl-Sørensen R; Brochmann N; Nielsen K; Thiele J; Jensen MK; Weis Bjerrum O; Kruse TA; Hasselbalch HC PLoS One 2016[]; 11 (8): ä PMID27579896show ga Recent studies have shown that a large proportion of patients classified as essential thrombocythemia (ET) actually have early primary prefibrotic myelofibrosis (prePMF), which implies an inferior prognosis as compared to patients being diagnosed with so-called genuine or true ET. According to the World Health Organization (WHO) 2008 classification, bone marrow histology is a major component in the distinction between these disease entities. However, the differential diagnosis between them may be challenging and several studies have not been able to distinguish between them. Most lately, it has been argued that simple blood tests, including the leukocyte count and plasma lactate dehydrogenase (LDH) may be useful tools to separate genuine ET from prePMF, the latter disease entity more often being featured by anemia, leukocytosis and elevated LDH. Whole blood gene expression profiling was performed in 17 and 9 patients diagnosed with ET and PMF, respectively. Using elevated LDH obtained at the time of diagnosis as a marker of prePMF, a 7-gene signature was identified which correctly predicted the prePMF group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8, which are genes known to be involved in inflammation, cell adhesion, differentiation and proliferation. Evaluation of bone marrow biopsies and the 7-gene signature showed a concordance rate of 71%, 79%, 62%, and 38%. Our 7-gene signature may be a useful tool to differentiate between genuine ET and prePMF but needs to be validated in a larger cohort of ?ET? patients. äA 7-Gene Signature Depicts the Biochemical Profile of Early Prefibroti(epmc).pdf DeepDyve Pubget Overpricing