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10.1080/2162402X.2016.1175800 http://scihub22266oqcxt.onion/10.1080/2162402X.2016.1175800 C5006916!5006916 !27622025     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27622025 &cmd=llinks): Failed to open stream: HTTP request failed! 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Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer |pdf=|usr=}}{{27622025 }} gab.com Text Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27622025 #FOAvip Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation. The goal of our study was to characterize CRC-infiltrating Tregs at multiple levels, by phenotypical, molecular and functional evaluation of Tregs from the tumor site, compared to non-tumoral mucosa and peripheral blood of CRC patients. The frequency of Tregs was higher in mucosa than in blood, and further significantly increased in tumor. Ex vivo, those Tregs suppressed the proliferation of tumor-infiltrating CD8(+) and CD4(+) T cells. A differential compartmentalization was detected between Helios(high) and Helios(low) Treg subsets (thymus-derived versus peripherally induced): while Helios(low) Tregs were enriched in both sites, only Helios(high) Tregs accumulated significantly and specifically in tumors, displayed a highly demethylated TSDR region and contained high proportions of cells expressing CD39 and OX40, markers of activation and suppression. Besides the suppression of T cells, Tregs may contribute to CRC progression also through releasing IL-17, or differentiating into Tfr cells that potentially antagonize a protective Tfh response, events that were both detected in tumor-associated Tregs. Overall, our data indicate that Treg accumulation may contribute through multiple mechanisms to CRC establishment and progression. Twit Text FOAVip Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27622025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27622025 #FOAvip English Wikipedia <ref>{{Cite pmid|27622025 }}</ref> Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer #MMPMID27622025 Timperi E ; Pacella I ; Schinzari V ; Focaccetti C ; Sacco L ; Farelli F ; Caronna R ; Del Bene G ; Longo F ; Ciardi A ; Morelli S ; Vestri AR ; Chirletti P ; Barnaba V ; Piconese S Oncoimmunology 2016[Jul]; 5 (7 ): e1175800 PMID27622025 show ga Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation. The goal of our study was to characterize CRC-infiltrating Tregs at multiple levels, by phenotypical, molecular and functional evaluation of Tregs from the tumor site, compared to non-tumoral mucosa and peripheral blood of CRC patients. The frequency of Tregs was higher in mucosa than in blood, and further significantly increased in tumor. Ex vivo, those Tregs suppressed the proliferation of tumor-infiltrating CD8(+) and CD4(+) T cells. A differential compartmentalization was detected between Helios(high) and Helios(low) Treg subsets (thymus-derived versus peripherally induced): while Helios(low) Tregs were enriched in both sites, only Helios(high) Tregs accumulated significantly and specifically in tumors, displayed a highly demethylated TSDR region and contained high proportions of cells expressing CD39 and OX40, markers of activation and suppression. Besides the suppression of T cells, Tregs may contribute to CRC progression also through releasing IL-17, or differentiating into Tfr cells that potentially antagonize a protective Tfh response, events that were both detected in tumor-associated Tregs. Overall, our data indicate that Treg accumulation may contribute through multiple mechanisms to CRC establishment and progression. äRegulatory T cells with multiple suppressive and potentially pro-tumor(epmc).pdf DeepDyve Pubget Overpricing