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2016 ; 5
(7
): e1182278
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The dual role of tumor lymphatic vessels in dissemination of metastases and
immune response development
#MMPMID27622039
Stachura J
; Wachowska M
; Kilarski WW
; Güç E
; Golab J
; Muchowicz A
Oncoimmunology
2016[Jul]; 5
(7
): e1182278
PMID27622039
show ga
Lymphatic vasculature plays a crucial role in the immune response, enabling
transport of dendritic cells (DCs) and antigens (Ags) into the lymph nodes.
Unfortunately, the lymphatic system has also a negative role in the progression
of cancer diseases, by facilitating the metastatic spread of many carcinomas to
the draining lymph nodes. The lymphatics can promote antitumor immune response as
well as tumor tolerance. Here, we review the role of lymphatic endothelial cells
(LECs) in tumor progression and immunity and mechanism of action in the newest
anti-lymphatic therapies, including photodynamic therapy (PDT).