The epigenome: the next substrate for engineering #MMPMID27582168
Park M; Keung AJ; Khalil AS
Genome Biol 2016[]; 17 (1): ä PMID27582168show ga
We are entering an era of epigenome engineering. The precision manipulation of chromatin and epigenetic modifications provides new ways to interrogate their influence on genome and cell function and to harness these changes for applications. We review the design and state of epigenome editing tools, highlighting the unique regulatory properties afforded by these systems.