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10.1093/ijnp/pyw025

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C5006197!5006197!27207923
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suck abstract from ncbi


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pmid27207923      Int+J+Neuropsychopharmacol 2016 ; 19 (8): ä
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  • Repetitive Transcranial Magnetic Stimulation to Supplementary Motor Area in Refractory Obsessive-Compulsive Disorder Treatment: a Sham-Controlled Trial #MMPMID27207923
  • Pelissolo A; Harika-Germaneau G; Rachid F; Gaudeau-Bosma C; Tanguy ML; BenAdhira R; Bouaziz N; Popa T; Wassouf I; Saba G; Januel D; Jaafari N
  • Int J Neuropsychopharmacol 2016[Aug]; 19 (8): ä PMID27207923show ga
  • Background:: Repetitive transcranial magnetic stimulation has been explored in patients with obsessive-compulsive disorder, but with negative or conflicting results. This randomized double-blind study was designed to assess the efficacy of 1-Hz repetitive transcranial magnetic stimulation over the presupplementary area. Methods:: Forty medication-resistant patients were assigned to 4 weeks of either active or sham repetitive transcranial magnetic stimulation targeting the presupplementary area with the help of a neuronavigation system. Results:: According to the Yale-Brown obsessive-compulsive scale, the baseline-week 4 evolution showed no significant differences between groups. Responder rates at week 4 were not different between groups (repetitive transcranial magnetic stimulation 10.5% vs sham 20%; P=.63). Conclusion:: Low-frequency repetitive transcranial magnetic stimulation applied to the presupplementary area seems ineffective for the treatment of obsessive-compulsive disorder patients, at least in severe and drug-refractory cases such as those included in this study. Further research is required to determine profiles of responder patients and appropriate repetitive transcranial magnetic stimulation parameters for obsessive-compulsive disorder.
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