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10.1038/srep32257 http://scihub22266oqcxt.onion/10.1038/srep32257 C5006047!5006047 !27577858     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27577858 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 32257 Nephropedia Template TP {{tp|p=27577858 |t=2016. Acetylated ?-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica |pdf=|usr=}}{{27577858 }} gab.com Text Acetylated -Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27577858 #FOAvip Silicosis is the most serious occupational disease in China. The objective of this study was to screen various proteins related to mechanisms of the pathogenesis of silicosis underlying the anti-fibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) using proteomic profile analysis. We also aimed to explore a potential mechanism of acetylated ?-tubulin (?-Ac-Tub) regulation by Ac-SDKP. Two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/TOF MS) were used to assess the different protein expression profiles between control and silicosis rats treated with or without Ac-SDKP. Twenty-nine proteins were identified to be potentially involved in the progression of silicosis and the anti-fibrotic effect of Ac-SDKP. Our current study finds that 1) the lost expression of Ac-Tub-? may be a new mechanism in rat silicosis; 2) treatment of silicotic rats with N-acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) inhibits myofibroblast differentiation and collagen deposition accompanied by stabilizing the expression of ?-Ac-Tub in vivo and in vitro, which is related with deacetylase family member 6 (HDAC6) and ?-tubulin acetyl transferase (?-TAT1). Our data suggest that ?-Ac-Tub regulation by Ac-SDKP may potentially be a new anti-fibrosis mechanism. Twit Text FOAVip Acetylated -Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27577858 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27577858 #FOAvip English Wikipedia <ref>{{Cite pmid|27577858 }}</ref> Acetylated ?-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica #MMPMID27577858 Xiaojun W ; Yan L ; Hong X ; Xianghong Z ; Shifeng L ; Dingjie X ; Xuemin G ; Lijuan Z ; Bonan Z ; Zhongqiu W ; Ruimin W ; Brann D ; Fang Y Sci Rep 2016[Aug]; 6 (ä): 32257 PMID27577858 show ga Silicosis is the most serious occupational disease in China. The objective of this study was to screen various proteins related to mechanisms of the pathogenesis of silicosis underlying the anti-fibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) using proteomic profile analysis. We also aimed to explore a potential mechanism of acetylated ?-tubulin (?-Ac-Tub) regulation by Ac-SDKP. Two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/TOF MS) were used to assess the different protein expression profiles between control and silicosis rats treated with or without Ac-SDKP. Twenty-nine proteins were identified to be potentially involved in the progression of silicosis and the anti-fibrotic effect of Ac-SDKP. Our current study finds that 1) the lost expression of Ac-Tub-? may be a new mechanism in rat silicosis; 2) treatment of silicotic rats with N-acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) inhibits myofibroblast differentiation and collagen deposition accompanied by stabilizing the expression of ?-Ac-Tub in vivo and in vitro, which is related with deacetylase family member 6 (HDAC6) and ?-tubulin acetyl transferase (?-TAT1). Our data suggest that ?-Ac-Tub regulation by Ac-SDKP may potentially be a new anti-fibrosis mechanism. |*Protein Processing, Post-Translational [MESH] |Acetylation [MESH] |Acetyltransferases/metabolism [MESH] |Actins/metabolism [MESH] |Amino Acid Sequence [MESH] |Angiotensin II/physiology [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Fibroblasts/metabolism [MESH] |Gene Ontology [MESH] |Histone Deacetylase 6/metabolism [MESH] |Lung/metabolism/pathology [MESH] |Male [MESH] |Protective Factors [MESH] |Protein Stability [MESH] |Pulmonary Fibrosis/chemically induced/*metabolism [MESH] |Rats, Wistar [MESH] |Silicon Dioxide [MESH] |Silicosis/*metabolism [MESH]Acetylated ?-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Prolin(epmc).pdf DeepDyve Pubget Overpricing