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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Clin+Microbiol 2016 ; 54 (9): 2225-32 Nephropedia Template TP
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New Gram-Positive Agents: the Next Generation of Oxazolidinones and Lipoglycopeptides #MMPMID26962092
Crotty MP; Krekel T; Burnham CAD; Ritchie DJ
J Clin Microbiol 2016[Sep]; 54 (9): 2225-32 PMID26962092show ga
The growing problem of antimicrobial resistance among bacterial pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), has reached a critical state. Tedizolid phosphate, dalbavancin, and oritavancin have recently been approved by the U.S. Food and Drug Administration (FDA) for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and represent the next generation of oxazolidinones and lipoglycopeptides. All three agents exhibit in vitro activity and clinical efficacy against MRSA. Tedizolid phosphate and oritavancin demonstrate in vitro activity against VRE. These new Gram-positive agents are reviewed here.