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2016 ; 24
(9
): 544-51
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Safety and efficacy of a device to narrow the coronary sinus for the treatment of
refractory angina: A single-centre real-world experience
#MMPMID27299456
Abawi M
; Nijhoff F
; Stella PR
; Voskuil M
; Benedetto D
; Doevendans PA
; Agostoni P
Neth Heart J
2016[Sep]; 24
(9
): 544-51
PMID27299456
show ga
OBJECTIVE: The coronary sinus Reducer is a recently introduced device to treat
patients with severe angina symptoms refractory to optimal medical therapy and
not amenable for conventional revascularisation. We aimed to assess the safety
and efficacy of the Reducer in a real-world cohort of patients with refractory
angina. METHODS: This is a single-centre retrospective registry. Patients with
severe angina symptoms, objective evidence of myocardial ischaemia using any
adequate non-invasive modality and without options for conventional
revascularisation were regarded eligible for Reducer implantation. RESULTS:
Twenty-three patients (74?% male, mean age 70?±?8 years, 91.3?% previous bypass
surgery, 82.6?% previous percutaneous intervention, 47.8?% previous myocardial
infarction, 52.2?% diabetes mellitus) underwent Reducer implantation. The safety
endpoint (successful implantation of the first device without device-related
adverse events) was met in all patients. After a median follow-up of 9 (8-14)
months the efficacy (any reduction in Canadian Cardiovascular Society (CCS) class
and revascularisation-free survival) was reached in 17 patients (74?%):
8 patients (34.8?%) improved by 1 CCS class, 7 (30.4?%) by 2 CCS classes and 2
(8.7?%) by 3 CCS classes. One patient died 4 months after implantation because of
progressive heart failure (not associated with Reducer implantation). CONCLUSION:
In this single-centre real-world experience, Reducer implantation was safe and
demonstrated excellent clinical efficacy in the treatment of refractory angina at
mid-term follow-up.