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10.1242/jcs.191262 http://scihub22266oqcxt.onion/10.1242/jcs.191262 C5004899!5004899!27369768     free     free     free       J+Cell+Sci 2016 ; 129 (16): 3077-83 Nephropedia Template TP {{tp|p=27369768|t=2016. Architecture of the caveolar coat complex |pdf=|usr=}}{{27369768}} gab.com Text Architecture of the caveolar coat complex JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=27369768 #FOAvip Caveolae are specialized membrane domains that are crucial for the correct function of endothelial cells, adipocytes and muscle cells. Caveolins and cavins are both required for caveolae formation, and assemble into a large (80S) caveolar coat complex (80S-CCC). The architecture of the 80S-CCC, however, has not been analyzed. Here, we study the 80S-CCC isolated from mammalian cells using negative stain electron microscopy and 3D cryo-electron tomography. We show that the 80S-CCC is a hollow sphere with a diameter of 50?80?nm, and so has the same size and shape as individual caveolar bulbs. This provides strong evidence that the distinctive membrane shape of caveolae is generated by the shape of the 80S-CCC itself. The particle appears to be made up of two layers, an inner coat composed of polygonal units of caveolins that form a polyhedral cage, and an outer filamentous coat composed of cavins. The data suggest that the peripheral cavin coat is aligned along the edges of the inner polyhedral cage, thereby providing a mechanism for the generation of a morphologically stable caveolar coat. Twit Text FOAVip Architecture of the caveolar coat complex ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=27369768 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27369768 #FOAvip English Wikipedia <ref>{{Cite pmid|27369768}}</ref> Architecture of the caveolar coat complex #MMPMID27369768 Ludwig A; Nichols BJ; Sandin S J Cell Sci 2016[Aug]; 129 (16): 3077-83 PMID27369768show ga Caveolae are specialized membrane domains that are crucial for the correct function of endothelial cells, adipocytes and muscle cells. Caveolins and cavins are both required for caveolae formation, and assemble into a large (80S) caveolar coat complex (80S-CCC). The architecture of the 80S-CCC, however, has not been analyzed. Here, we study the 80S-CCC isolated from mammalian cells using negative stain electron microscopy and 3D cryo-electron tomography. We show that the 80S-CCC is a hollow sphere with a diameter of 50?80?nm, and so has the same size and shape as individual caveolar bulbs. This provides strong evidence that the distinctive membrane shape of caveolae is generated by the shape of the 80S-CCC itself. The particle appears to be made up of two layers, an inner coat composed of polygonal units of caveolins that form a polyhedral cage, and an outer filamentous coat composed of cavins. The data suggest that the peripheral cavin coat is aligned along the edges of the inner polyhedral cage, thereby providing a mechanism for the generation of a morphologically stable caveolar coat. äArchitecture of the caveolar coat complex (epmc).pdf DeepDyve Pubget Overpricing