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10.1080/15384047.2016.1195040 http://scihub22266oqcxt.onion/10.1080/15384047.2016.1195040 C5004686!5004686!27260617     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Biol+Ther 2016 ; 17 (8): 790-8 Nephropedia Template TP {{tp|p=27260617|t=2016. A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1? |pdf=|usr=}}{{27260617}} gab.com Text A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1 JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=27260617 #FOAvip Hypoxia is a general event in solid tumor growth. Therefore, induced cellular responses by hypoxia are important for tumorigenesis and tumor growth. MicroRNAs (miRNAs) have recently emerged as important regulators of hypoxia induced cellular responses. Here we report that miR-147a is a novel and crucial hypoxia induced miRNA. HIF-1? up-regulates the expression of miR-147a, and miR-147a in turn stabilizes and accumulates HIF-1? protein via directly targeting HIF-3?, a dominant negative regulator of HIF-1?. Subsequent studies in xenograft mouse model reveal that miR-147a is capable of inhibiting tumor growth. Collectively, these data demonstrate a positive feedback loop between HIF-1?, miR-147a and HIF-3?, which provide a new insight into the mechanism of miR-147a induced cell proliferation arrest under hypoxia. Twit Text FOAVip A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1 ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=27260617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27260617 #FOAvip English Wikipedia <ref>{{Cite pmid|27260617}}</ref> A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1? #MMPMID27260617 Wang F; Zhang H; Xu N; Huang N; Tian C; Ye A; Hu G; He J; Zhang Y Cancer Biol Ther 2016[Aug]; 17 (8): 790-8 PMID27260617show ga Hypoxia is a general event in solid tumor growth. Therefore, induced cellular responses by hypoxia are important for tumorigenesis and tumor growth. MicroRNAs (miRNAs) have recently emerged as important regulators of hypoxia induced cellular responses. Here we report that miR-147a is a novel and crucial hypoxia induced miRNA. HIF-1? up-regulates the expression of miR-147a, and miR-147a in turn stabilizes and accumulates HIF-1? protein via directly targeting HIF-3?, a dominant negative regulator of HIF-1?. Subsequent studies in xenograft mouse model reveal that miR-147a is capable of inhibiting tumor growth. Collectively, these data demonstrate a positive feedback loop between HIF-1?, miR-147a and HIF-3?, which provide a new insight into the mechanism of miR-147a induced cell proliferation arrest under hypoxia. äA novel hypoxia-induced miR-147a regulates cell proliferation through (epmc).pdf DeepDyve Pubget Overpricing