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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Cycle 2016 ; 15 (17): 2256-62 Nephropedia Template TP
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Association between EZH2 expression, silencing of tumor suppressors and disease outcome in solid tumors #MMPMID27419533
Wassef M; Michaud A; Margueron R
Cell Cycle 2016[]; 15 (17): 2256-62 PMID27419533show ga
EZH2, the main catalytic component of the Polycomb Repressive Complex 2 (PRC2) is apparently upregulated in most solid tumors. Furthermore its expression generally associates with poor prognosis. It was proposed that this correlation reflects a causal event, EZH2 mediating the silencing of key tumor suppressor loci. In contrast, we recently showed that EZH2 is dispensable for solid tumor development and that its elevated expression reflects the abnormally high proliferation rate of cancer cells. Here, we investigate the functional association between EZH2 expression and silencing of key tumor suppressor loci and further illustrate the confounding effect of proliferation on EZH2?s association to outcome.