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10.1681/ASN.2015060664 http://scihub22266oqcxt.onion/10.1681/ASN.2015060664 C5004650!5004650!26940093     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2016 ; 27 (9): 2762-70 Nephropedia Template TP {{tp|p=26940093|t=2016. Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells |pdf=|usr=}}{{26940093}} gab.com Text Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26940093 #FOAvip In humans, nephrogenesis is completed prenatally, with nephrons formed until 34 weeks of gestational age. We hypothesized that urine of preterm neonates born before the completion of nephrogenesis is a noninvasive source of highly potent stem/progenitor cells. To test this hypothesis, we collected freshly voided urine at day 1 after birth from neonates born at 31?36 weeks of gestational age and characterized isolated cells using a single?cell RT-PCR strategy for gene expression analysis and flow cytometry and immunofluorescence for protein expression analysis. Neonatal stem/progenitor cells expressed markers of nephron progenitors but also, stromal progenitors, with many single cells coexpressing these markers. Furthermore, these cells presented mesenchymal stem cell features and protected cocultured tubule cells from cisplatin-induced apoptosis. Podocytes differentiated from the neonatal stem/progenitor cells showed upregulation of podocyte-specific genes and proteins, albumin endocytosis, and calcium influx via podocyte?specific transient receptor potential cation channel, subfamily C, member 6. Differentiated proximal tubule cells showed upregulation of specific genes and significantly elevated p-glycoprotein activity. We conclude that urine of preterm neonates is a novel noninvasive source of kidney progenitors that are capable of differentiation into mature kidney cells and have high potential for regenerative kidney repair. Twit Text FOAVip Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26940093 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26940093 #FOAvip English Wikipedia <ref>{{Cite pmid|26940093}}</ref> Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells #MMPMID26940093 Arcolino FO; Zia S; Held K; Papadimitriou E; Theunis K; Bussolati B; Raaijmakers A; Allegaert K; Voet T; Deprest J; Vriens J; Toelen J; van den Heuvel L; Levtchenko E J Am Soc Nephrol 2016[Sep]; 27 (9): 2762-70 PMID26940093show ga In humans, nephrogenesis is completed prenatally, with nephrons formed until 34 weeks of gestational age. We hypothesized that urine of preterm neonates born before the completion of nephrogenesis is a noninvasive source of highly potent stem/progenitor cells. To test this hypothesis, we collected freshly voided urine at day 1 after birth from neonates born at 31?36 weeks of gestational age and characterized isolated cells using a single?cell RT-PCR strategy for gene expression analysis and flow cytometry and immunofluorescence for protein expression analysis. Neonatal stem/progenitor cells expressed markers of nephron progenitors but also, stromal progenitors, with many single cells coexpressing these markers. Furthermore, these cells presented mesenchymal stem cell features and protected cocultured tubule cells from cisplatin-induced apoptosis. Podocytes differentiated from the neonatal stem/progenitor cells showed upregulation of podocyte-specific genes and proteins, albumin endocytosis, and calcium influx via podocyte?specific transient receptor potential cation channel, subfamily C, member 6. Differentiated proximal tubule cells showed upregulation of specific genes and significantly elevated p-glycoprotein activity. We conclude that urine of preterm neonates is a novel noninvasive source of kidney progenitors that are capable of differentiation into mature kidney cells and have high potential for regenerative kidney repair. äUrine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells(epmc).pdf DeepDyve Pubget Overpricing