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10.1681/ASN.2015040439 http://scihub22266oqcxt.onion/10.1681/ASN.2015040439 C5004642!5004642!26839367     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2016 ; 27 (9): 2616-21 Nephropedia Template TP {{tp|p=26839367|t=2016. Role of Receptor Protein Tyrosine Phosphatase ? in Sensing Extracellular CO2 and HCO3? |pdf=|usr=}}{{26839367}} gab.com Text Role of Receptor Protein Tyrosine Phosphatase in Sensing Extracellular CO2 and HCO3 JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26839367 #FOAvip Regulation of blood pH?critical for virtually every facet of life?requires that the renal proximal tubule (PT) adjust its rate of H+ secretion (nearly the same as the rate of HCO3? reabsorption, JHCO3) in response to changes in blood [CO2] and [HCO3?]. Yet CO2/HCO3? sensing mechanisms remain poorly characterized. Because receptor tyrosine kinase inhibitors render JHCO3 in the PT insensitive to changes in CO2 concentration, we hypothesized that the structural features of receptor protein tyrosine phosphatase-? (RPTP?) that are consistent with binding of extracellular CO2 or HCO3? facilitate monitoring of blood CO2/HCO3? concentrations. We now report that PTs express RPTP? on blood-facing membranes. Moreover, RPTP? deletion in mice eliminated the CO2 and HCO3? sensitivities of JHCO3 as well as the normal defense of blood pH during whole-body acidosis. Thus, RPTP? appears to be a novel extracellular CO2/HCO3? sensor critical for pH homeostasis. Twit Text FOAVip Role of Receptor Protein Tyrosine Phosphatase in Sensing Extracellular CO2 and HCO3 ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26839367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26839367 #FOAvip English Wikipedia <ref>{{Cite pmid|26839367}}</ref> Role of Receptor Protein Tyrosine Phosphatase ? in Sensing Extracellular CO2 and HCO3? #MMPMID26839367 Zhou Y; Skelton LA; Xu L; Chandler MP; Berthiaume JM; Boron WF J Am Soc Nephrol 2016[Sep]; 27 (9): 2616-21 PMID26839367show ga Regulation of blood pH?critical for virtually every facet of life?requires that the renal proximal tubule (PT) adjust its rate of H+ secretion (nearly the same as the rate of HCO3? reabsorption, JHCO3) in response to changes in blood [CO2] and [HCO3?]. Yet CO2/HCO3? sensing mechanisms remain poorly characterized. Because receptor tyrosine kinase inhibitors render JHCO3 in the PT insensitive to changes in CO2 concentration, we hypothesized that the structural features of receptor protein tyrosine phosphatase-? (RPTP?) that are consistent with binding of extracellular CO2 or HCO3? facilitate monitoring of blood CO2/HCO3? concentrations. We now report that PTs express RPTP? on blood-facing membranes. Moreover, RPTP? deletion in mice eliminated the CO2 and HCO3? sensitivities of JHCO3 as well as the normal defense of blood pH during whole-body acidosis. Thus, RPTP? appears to be a novel extracellular CO2/HCO3? sensor critical for pH homeostasis. äRole of Receptor Protein Tyrosine Phosphatase ? in Sensing Extracellul(epmc).pdf DeepDyve Pubget Overpricing