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10.6061/clinics/2016(09)11

http://scihub22266oqcxt.onion/10.6061/clinics/2016(09)11
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suck abstract from ncbi


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pmid27652838
      Clinics+(Sao+Paulo) 2016 ; 71 (9 ): 550-4
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  • Clinical features and outcomes of diffuse endocapillary proliferation Henoch-Schönlein purpura nephritis in children #MMPMID27652838
  • Fu H ; Mao J ; Xu Y ; Gu W ; Zhu X ; Liu A
  • Clinics (Sao Paulo) 2016[Sep]; 71 (9 ): 550-4 PMID27652838 show ga
  • OBJECTIVE: To investigate the outcomes of childhood diffuse endocapillary proliferation Henoch-Schönlein purpura nephritis (DEP-HSPN) in response to early diagnosis and prompt treatment. METHODS: Eleven cases of DEP-HSPN in children were investigated in comparison to HSPN without diffuse endocapillary proliferation (non-DEP-HSPN). RESULTS: DEP-HSPN had a higher prevalence of nephrotic syndrome but a lower prevalence of hematuria compared to non-DEP-HSPN. IgA, IgG and IgM antibody deposition was found in DEP-HSPN by histopathological examination. Proteinuria cleared in all 11 cases through treatment with steroids and/or immunosuppressive drugs. However, half of the DEP-HSPN patients continuously had hematuria after treatment. CONCLUSION: The early diagnosis and prompt initiation of immunosuppressive treatment based on renal biopsy are important for achieving favorable outcomes.
  • |Adolescent [MESH]
  • |Biopsy [MESH]
  • |Child [MESH]
  • |Child, Preschool [MESH]
  • |Female [MESH]
  • |Glucocorticoids/therapeutic use [MESH]
  • |Hematuria [MESH]
  • |Humans [MESH]
  • |IgA Vasculitis/*drug therapy/*pathology [MESH]
  • |Immunosuppressive Agents/therapeutic use [MESH]
  • |Kidney/pathology [MESH]
  • |Male [MESH]
  • |Nephritis/*drug therapy/*pathology [MESH]
  • |Prednisone/therapeutic use [MESH]
  • |Proteinuria [MESH]


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