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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Haematologica 2015 ; 100 (8): 997-1004 Nephropedia Template TP
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Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies #MMPMID26314082
Lehmberg K; Nichols KE; Henter JI; Girschikofsky M; Greenwood T; Jordan M; Kumar A; Minkov M; La Rosée P; Weitzman S
Haematologica 2015[Aug]; 100 (8): 997-1004 PMID26314082show ga
The hyperinflammatory syndrome hemophagocytic lymphohistiocytosis can occur in the context of malignancies. Malignancy-triggered hemophagocytic lymphohistiocytosis should be regarded seperately from hemophagocytic lymphohistiocytosis during chemotherapeutic treatment, which is frequently associated with an infectious trigger. The substantial overlap between the features of hemophagocytic lymphohistiocytosis with features of neoplasms makes its identification difficult when it occurs in malignant conditions. To facilitate recognition and diagnostic workup, and provide guidance regarding the treatment of malignancy-associated hemophagocytic lymphohistiocytosis, consensus recommendations were developed by the Study Group on Hemophagocytic Lymphohistiocytosis Subtypes of the Histiocyte Society, an interdisciplinary group consisting of pediatric and adult hemato-oncologists and immunologists.