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10.3324/haematol.2015.139139 http://scihub22266oqcxt.onion/10.3324/haematol.2015.139139 C5004382!5004382 !26921359     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26921359 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Haematologica 2016 ; 101 (5 ): 578-86 Nephropedia Template TP {{tp|p=26921359 |t=2016. Metabolic pathways that correlate with post-transfusion circulation of stored murine red blood cells |pdf=|usr=}}{{26921359 }} gab.com Text Metabolic pathways that correlate with post-transfusion circulation of stored murine red blood cells JO: Haematologica http://www.kidney.de/pget.php?&tw=1&pmid=26921359 #FOAvip Transfusion of red blood cells is a very common inpatient procedure, with more than 1 in 70 people in the USA receiving a red blood cell transfusion annually. However, stored red blood cells are a non-uniform product, based upon donor-to-donor variation in red blood cell storage biology. While thousands of biological parameters change in red blood cells over storage, it has remained unclear which changes correlate with function of the red blood cells, as opposed to being co-incidental changes. In the current report, a murine model of red blood cell storage/transfusion is applied across 13 genetically distinct mouse strains and combined with high resolution metabolomics to identify metabolic changes that correlated with red blood cell circulation post storage. Oxidation in general, and peroxidation of lipids in particular, emerged as changes that correlated with extreme statistical significance, including generation of dicarboxylic acids and monohydroxy fatty acids. In addition, differences in anti-oxidant pathways known to regulate oxidative stress on lipid membranes were identified. Finally, metabolites were identified that differed at the time the blood was harvested, and predict how the red blood cells perform after storage, allowing the potential to screen donors at time of collection. Together, these findings map out a new landscape in understanding metabolic changes during red blood cell storage as they relate to red blood cell circulation. Twit Text FOAVip Metabolic pathways that correlate with post-transfusion circulation of stored murine red blood cells ????Haematologica http://www.kidney.de/pget.php?&tw=1&pmid=26921359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26921359 #FOAvip English Wikipedia <ref>{{Cite pmid|26921359 }}</ref> Metabolic pathways that correlate with post-transfusion circulation of stored murine red blood cells #MMPMID26921359 de Wolski K ; Fu X ; Dumont LJ ; Roback JD ; Waterman H ; Odem-Davis K ; Howie HL ; Zimring JC Haematologica 2016[May]; 101 (5 ): 578-86 PMID26921359 show ga Transfusion of red blood cells is a very common inpatient procedure, with more than 1 in 70 people in the USA receiving a red blood cell transfusion annually. However, stored red blood cells are a non-uniform product, based upon donor-to-donor variation in red blood cell storage biology. While thousands of biological parameters change in red blood cells over storage, it has remained unclear which changes correlate with function of the red blood cells, as opposed to being co-incidental changes. In the current report, a murine model of red blood cell storage/transfusion is applied across 13 genetically distinct mouse strains and combined with high resolution metabolomics to identify metabolic changes that correlated with red blood cell circulation post storage. Oxidation in general, and peroxidation of lipids in particular, emerged as changes that correlated with extreme statistical significance, including generation of dicarboxylic acids and monohydroxy fatty acids. In addition, differences in anti-oxidant pathways known to regulate oxidative stress on lipid membranes were identified. Finally, metabolites were identified that differed at the time the blood was harvested, and predict how the red blood cells perform after storage, allowing the potential to screen donors at time of collection. Together, these findings map out a new landscape in understanding metabolic changes during red blood cell storage as they relate to red blood cell circulation. |*Blood Preservation/adverse effects [MESH] |*Metabolic Networks and Pathways [MESH] |Animals [MESH] |Antioxidants/metabolism [MESH] |Blood Transfusion [MESH] |Erythrocyte Transfusion [MESH] |Erythrocytes/*metabolism [MESH] |Female [MESH] |Genetic Association Studies [MESH] |Glucose/metabolism [MESH] |Male [MESH] |Metabolome [MESH] |Metabolomics/methods [MESH] |Mice [MESH] |Mice, Inbred Strains [MESH] |Oxidation-Reduction [MESH] |Species Specificity [MESH]Metabolic pathways that correlate with post-transfusion circulation of(epmc).pdf DeepDyve Pubget Overpricing