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10.3324/haematol.2015.139493

http://scihub22266oqcxt.onion/10.3324/haematol.2015.139493
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C5004369!5004369!27132279
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suck abstract from ncbi


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pmid27132279      Haematologica 2016 ; 101 (5): 531-40
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  • Role of the tumor microenvironment in mature B-cell lymphoid malignancies #MMPMID27132279
  • Fowler NH; Cheah CY; Gascoyne RD; Gribben J; Neelapu SS; Ghia P; Bollard C; Ansell S; Curran M; Wilson WH; O?Brien S; Grant C; Little R; Zenz T; Nastoupil LJ; Dunleavy K
  • Haematologica 2016[May]; 101 (5): 531-40 PMID27132279show ga
  • The tumor microenvironment is the cellular and molecular environment in which the tumor exists and with which it continuously interacts. In B-cell lymphomas, this microenvironment is intriguing in that it plays critical roles in the regulation of tumor cell survival and proliferation, fostering immune escape as well as the development of treatment resistance. The purpose of this review is to summarize the proceedings of the Second Annual Summit on the Immune Microenvironment in Hematologic Malignancies that took place on September 11?12, 2014 in Dublin, Ireland. We provide a timely overview of the composition and biological relevance of the cellular and molecular microenvironment interface and discuss the role of interactions between the microenvironment and neoplastic cells in a variety of B-cell lymphomas. In addition, we focus on various novel therapeutic strategies that target the tumor microenvironment, including agents that modulate B-cell receptor pathways and immune-checkpoints, chimeric antigen receptor T cells and immunomodulatory agents.
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