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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Obstet+Med 2013 ; 6 (4): 159-64 Nephropedia Template TP
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Pregnancies complicated by preeclampsia and non-preeclampsia-related nephrotic range proteinuria #MMPMID27656249
Brown R; Kemp G; Walkinshaw S; Howse M
Obstet Med 2013[Dec]; 6 (4): 159-64 PMID27656249show ga
Objective: To examine the impact of nephrotic range proteinuria during pregnancy on renal, maternal and fetal outcomes. Methods: A retrospective study of pregnant women with proteinuria greater than 3?g/24?h. Outcome measures included: gestation and mode of delivery, maternal high dependency unit admission, birth weight, maternal blood pressure and proteinuria at time of last follow-up, renal biopsy. Results: Two hundred and sixty four pregnancies in 262 women were reviewed. Postnatal data were available in 180; of these 104 (57%) had urinary protein quantified postnatally. Sixty three (60%) were pure preeclampsia and nine (9%) super-imposed preeclampsia. Biopsy-proven renal disease was newly diagnosed in nine (9%). Sixty three per cent required caesarean section and 34% required high dependency unit admission. There were no maternal deaths. Birth weight corrected for gestation was below the fifth centile in 33%. Conclusions: The incidence of underlying renal pathology in this cohort is significant and highlights the importance of careful follow-up.