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10.1007/s13238-016-0285-2 http://scihub22266oqcxt.onion/10.1007/s13238-016-0285-2 C5003784!5003784 !27342773     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27342773 &cmd=llinks): Failed to open stream: HTTP request failed! 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Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells |pdf=|usr=}}{{27342773 }} gab.com Text Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells JO: Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=27342773 #FOAvip Matrine (MT), the effective component of Sophora flavescens Ait, has been shown to have anti-inflammation, immune-suppressive, anti-tumor, and anti-hepatic fibrosis activities. However, the pharmacological effects of MT still need to be strengthened due to its relatively low efficacy and short half-life. In the present study, we report a more effective thio derivative of MT, MD-1, and its inhibitory effects on the activation of hepatic stellate cells (HSCs) in both cell culture and animal models. Cytological experiments showed that MD-1 can inhibit the proliferation of HSC-T6 cells with a half-maximal inhibitory concentration (IC50) of 62 ?mol/L. In addition, MD-1 more strongly inhibits the migration of HSC-T6 cells compared to MT and can more effectively induce G0/G1 arrest and apoptosis. Investigating the biological mechanisms underlying anti-hepatic fibrosis in the presence of MD-1, we found that MD-1 can bind the epidermal growth factor receptor (EGFR) on the surface of HSC-T6 cells, which can further inhibit the phosphorylation of EGFR and its downstream protein kinase B (Akt), resulting in decreased expression of cyclin D1 and eventual inhibition of the activation of HSC-T6 cells. Furthermore, in rats with dimethylnitrosamine (DMN)-induced hepatic fibrosis, MD-1 slowed the development and progression of hepatic fibrosis, protecting hepatic parenchymal cells and improving hepatic functions. Therefore, MD-1 is a potential drug for anti-hepatic fibrosis. Twit Text FOAVip Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells ????Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=27342773 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27342773 #FOAvip English Wikipedia <ref>{{Cite pmid|27342773 }}</ref> Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells #MMPMID27342773 Feng Y ; Ying HY ; Qu Y ; Cai XB ; Xu MY ; Lu LG Protein Cell 2016[Sep]; 7 (9 ): 662-72 PMID27342773 show ga Matrine (MT), the effective component of Sophora flavescens Ait, has been shown to have anti-inflammation, immune-suppressive, anti-tumor, and anti-hepatic fibrosis activities. However, the pharmacological effects of MT still need to be strengthened due to its relatively low efficacy and short half-life. In the present study, we report a more effective thio derivative of MT, MD-1, and its inhibitory effects on the activation of hepatic stellate cells (HSCs) in both cell culture and animal models. Cytological experiments showed that MD-1 can inhibit the proliferation of HSC-T6 cells with a half-maximal inhibitory concentration (IC50) of 62 ?mol/L. In addition, MD-1 more strongly inhibits the migration of HSC-T6 cells compared to MT and can more effectively induce G0/G1 arrest and apoptosis. Investigating the biological mechanisms underlying anti-hepatic fibrosis in the presence of MD-1, we found that MD-1 can bind the epidermal growth factor receptor (EGFR) on the surface of HSC-T6 cells, which can further inhibit the phosphorylation of EGFR and its downstream protein kinase B (Akt), resulting in decreased expression of cyclin D1 and eventual inhibition of the activation of HSC-T6 cells. Furthermore, in rats with dimethylnitrosamine (DMN)-induced hepatic fibrosis, MD-1 slowed the development and progression of hepatic fibrosis, protecting hepatic parenchymal cells and improving hepatic functions. Therefore, MD-1 is a potential drug for anti-hepatic fibrosis. |Alkaloids/*pharmacology [MESH] |Animals [MESH] |Cell Line [MESH] |Cyclin D1/metabolism [MESH] |Dimethylnitrosamine/toxicity [MESH] |Enzyme Activation/drug effects [MESH] |ErbB Receptors/*metabolism [MESH] |G1 Phase Cell Cycle Checkpoints/drug effects [MESH] |Hepatic Stellate Cells/*metabolism/pathology [MESH] |Liver Cirrhosis/chemically induced/metabolism/pathology/*prevention & control [MESH] |Matrines [MESH] |Phosphorylation/drug effects [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Quinolizines/*pharmacology [MESH]Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibitin(epmc).pdf DeepDyve Pubget Overpricing