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10.1053/j.semdp.2016.05.006 http://scihub22266oqcxt.onion/10.1053/j.semdp.2016.05.006 C5003700!5003700!27296355     free     free     free       Semin+Diagn+Pathol 2016 ; 33 (5): 294-306 Nephropedia Template TP {{tp|p=27296355|t=2016. Multicentric Castleman Disease: Where are we now?|pdf=|usr=}}{{27296355}} gab.com Text Multicentric Castleman Disease: Where are we now JO: Semin Diagn Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27296355 #FOAvip Multicentric Castleman disease (MCD) encompasses a spectrum of conditions that give rise to overlapping clinicopathological manifestations. The fundamental pathogenetic mechanism involves dysregulated cytokine activity, which causes systemic inflammatory symptoms as well as lymphadenopathy. The histological changes in lymph nodes resemble in part the findings originally described in the unicentric forms Castleman disease, both hyaline vascular and plasma cell variants. In MCD caused by Kaposi sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV8), the cytokine over activity is caused by viral products, which can also lead to atypical lymphoproliferations and potential progression to lymphoma. In cases negative for KSHV/HHV8, so-called idiopathic MCD, the hypercytokinemia can result from various mechanisms, which ultimately lead to different constellations of clinical presentations and varied pathology in lymphoid tissues. In this article, we review the evolving concepts and definitions of the various conditions under the eponym of Castleman disease, and summarize current knowledge regarding the histopathology and pathogenesis of lesions within the MCD spectrum. Twit Text FOAVip Multicentric Castleman Disease: Where are we now ????Semin Diagn Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27296355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27296355 #FOAvip English Wikipedia <ref>{{Cite pmid|27296355}}</ref> Multicentric Castleman Disease: Where are we now? #MMPMID27296355 Wang HW; Pittaluga S; Jaffe ES Semin Diagn Pathol 2016[Sep]; 33 (5): 294-306 PMID27296355show ga Multicentric Castleman disease (MCD) encompasses a spectrum of conditions that give rise to overlapping clinicopathological manifestations. The fundamental pathogenetic mechanism involves dysregulated cytokine activity, which causes systemic inflammatory symptoms as well as lymphadenopathy. The histological changes in lymph nodes resemble in part the findings originally described in the unicentric forms Castleman disease, both hyaline vascular and plasma cell variants. In MCD caused by Kaposi sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV8), the cytokine over activity is caused by viral products, which can also lead to atypical lymphoproliferations and potential progression to lymphoma. In cases negative for KSHV/HHV8, so-called idiopathic MCD, the hypercytokinemia can result from various mechanisms, which ultimately lead to different constellations of clinical presentations and varied pathology in lymphoid tissues. In this article, we review the evolving concepts and definitions of the various conditions under the eponym of Castleman disease, and summarize current knowledge regarding the histopathology and pathogenesis of lesions within the MCD spectrum. äMulticentric Castleman Disease: Where are we now?(epmc).pdf DeepDyve Pubget Overpricing