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10.2147/IJN.S110146 http://scihub22266oqcxt.onion/10.2147/IJN.S110146 C5003564!5003564!27601898     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Nanomedicine 2016 ; 11 (ä): 4107-24 Nephropedia Template TP {{tp|p=27601898|t=2016. Nanomedicine engulfed by macrophages for targeted tumor therapy |pdf=|usr=}}{{27601898}} gab.com Text Nanomedicine engulfed by macrophages for targeted tumor therapy JO: Int J Nanomedicine http://www.kidney.de/pget.php?&tw=1&pmid=27601898 #FOAvip Macrophages, exhibiting high intrinsic accumulation and infiltration into tumor tissues, are a novel drug vehicle for directional drug delivery. However, the low drug-loading (DL) capacity and the drug cytotoxicity to the cell vehicle have limited the application of macrophages in tumor therapy. In this study, different drugs involving small molecular and nanoparticle drugs were loaded into intrinsic macrophages to find a better way to overcome these limitations. Their DL capacity and cytotoxicity to the macrophages were first compared. Furthermore, their phagocytic ratio, dynamic distributions, and tumoricidal effects were also investigated. Results indicated that more lipid-soluble molecules and DL particles can be phagocytized by macrophages than hydrophilic ones. In addition, the N-succinyl-N?-octyl chitosan (SOC) DL particles showed low cytotoxicity to the macrophage itself, while the dynamic biodistribution of macrophages engulfed with different particles/small molecules showed similar profiles, mainly excreted from liver to intestine pathway. Furthermore, macrophages loaded with SOC?paclitaxel (PTX) particles exhibited greater therapeutic efficacies than those of macrophages directly carrying small molecular drugs such as doxorubicin and PTX. Interestingly, macrophages displayed stronger targeting ability to the tumor site hypersecreting chemokine in immunocompetent mice in comparison to the tumor site secreting low levels of chemokine in immunodeficiency mice. Finally, results demonstrated that macrophages carrying SOC?PTX are a promising pharmaceutical preparation for tumor-targeted therapy. Twit Text FOAVip Nanomedicine engulfed by macrophages for targeted tumor therapy ????Int J Nanomedicine http://www.kidney.de/pget.php?&tw=1&pmid=27601898 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27601898 #FOAvip English Wikipedia <ref>{{Cite pmid|27601898}}</ref> Nanomedicine engulfed by macrophages for targeted tumor therapy #MMPMID27601898 Li S; Feng S; Ding L; Liu Y; Zhu Q; Qian Z; Gu Y Int J Nanomedicine 2016[]; 11 (ä): 4107-24 PMID27601898show ga Macrophages, exhibiting high intrinsic accumulation and infiltration into tumor tissues, are a novel drug vehicle for directional drug delivery. However, the low drug-loading (DL) capacity and the drug cytotoxicity to the cell vehicle have limited the application of macrophages in tumor therapy. In this study, different drugs involving small molecular and nanoparticle drugs were loaded into intrinsic macrophages to find a better way to overcome these limitations. Their DL capacity and cytotoxicity to the macrophages were first compared. Furthermore, their phagocytic ratio, dynamic distributions, and tumoricidal effects were also investigated. Results indicated that more lipid-soluble molecules and DL particles can be phagocytized by macrophages than hydrophilic ones. In addition, the N-succinyl-N?-octyl chitosan (SOC) DL particles showed low cytotoxicity to the macrophage itself, while the dynamic biodistribution of macrophages engulfed with different particles/small molecules showed similar profiles, mainly excreted from liver to intestine pathway. Furthermore, macrophages loaded with SOC?paclitaxel (PTX) particles exhibited greater therapeutic efficacies than those of macrophages directly carrying small molecular drugs such as doxorubicin and PTX. Interestingly, macrophages displayed stronger targeting ability to the tumor site hypersecreting chemokine in immunocompetent mice in comparison to the tumor site secreting low levels of chemokine in immunodeficiency mice. Finally, results demonstrated that macrophages carrying SOC?PTX are a promising pharmaceutical preparation for tumor-targeted therapy. äNanomedicine engulfed by macrophages for targeted tumor therapy (epmc).pdf DeepDyve Pubget Overpricing