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10.1080/21541248.2016.1173772

http://scihub22266oqcxt.onion/10.1080/21541248.2016.1173772
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C5003545!5003545!27152729
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suck abstract from ncbi


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pmid27152729      Small+GTPases 2016 ; 7 (3): 156-63
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  • P-cadherin-mediated Rho GTPase regulation during collective cell migration #MMPMID27152729
  • Plutoni C; Bazellières E; Gauthier-Rouvière C
  • Small GTPases 2016[Jul]; 7 (3): 156-63 PMID27152729show ga
  • This commentary addresses the role of P-cadherin in collective cell migration (CCM), a cooperative and coordinated migration mode, used by cells during normal and pathological migration processes. We discuss how cadherin-mediated cell-cell junctions (CCJs) play a critical role in CCM through their ability to regulate Rho GTPase-dependent pathways and how this leads to the generation and orientation of mechanical forces. We will also highlight the key function of P-cadherin (a poor prognostic marker in several tumors) in promoting collective cell movement in epithelial and mesenchymal cells.
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