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10.3390/microarrays2040304 http://scihub22266oqcxt.onion/10.3390/microarrays2040304 C5003441!5003441!27605194     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microarrays+(Basel) 2013 ; 2 (4): 304-17 Nephropedia Template TP {{tp|p=27605194|t=2013. Chromosomal Microarrays in Prenatal Diagnosis: Time for a Change of Policy?|pdf=|usr=}}{{27605194}} gab.com Text Chromosomal Microarrays in Prenatal Diagnosis: Time for a Change of Policy JO: Microarrays (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27605194 #FOAvip Microarrays have replaced conventional karyotyping as a first-tier test for unbalanced chromosome anomalies in postnatal cytogenetics mainly due to their unprecedented resolution facilitating the detection of submicroscopic copy number changes at a rate of 10?20% depending on indication for testing. A number of studies have addressed the performance of microarrays for chromosome analyses in high risk pregnancies due to abnormal ultrasound findings and reported an excess detection rate between 5% and 10%. In low risk pregnancies, clear pathogenic copy number changes at the submicroscopic level were encountered in 1% or less. Variants of unclear clinical significance, unsolicited findings, and copy number changes with variable phenotypic consequences are the main issues of concern in the prenatal setting posing difficult management questions. The benefit of microarray testing may be limited in pregnancies with only moderately increased risks (advanced maternal age, positive first trimester test). It is suggested to not change the current policy of microarray application in prenatal diagnosis until more data on the clinical significance of copy number changes are available. Twit Text FOAVip Chromosomal Microarrays in Prenatal Diagnosis: Time for a Change of Policy ????Microarrays (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27605194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27605194 #FOAvip English Wikipedia <ref>{{Cite pmid|27605194}}</ref> Chromosomal Microarrays in Prenatal Diagnosis: Time for a Change of Policy? #MMPMID27605194 Miny P; Wenzel F; Tercanli S; Filges I Microarrays (Basel) 2013[Dec]; 2 (4): 304-17 PMID27605194show ga Microarrays have replaced conventional karyotyping as a first-tier test for unbalanced chromosome anomalies in postnatal cytogenetics mainly due to their unprecedented resolution facilitating the detection of submicroscopic copy number changes at a rate of 10?20% depending on indication for testing. A number of studies have addressed the performance of microarrays for chromosome analyses in high risk pregnancies due to abnormal ultrasound findings and reported an excess detection rate between 5% and 10%. In low risk pregnancies, clear pathogenic copy number changes at the submicroscopic level were encountered in 1% or less. Variants of unclear clinical significance, unsolicited findings, and copy number changes with variable phenotypic consequences are the main issues of concern in the prenatal setting posing difficult management questions. The benefit of microarray testing may be limited in pregnancies with only moderately increased risks (advanced maternal age, positive first trimester test). It is suggested to not change the current policy of microarray application in prenatal diagnosis until more data on the clinical significance of copy number changes are available. äChromosomal Microarrays in Prenatal Diagnosis: Time for a Change of Po(epmc).pdf DeepDyve Pubget Overpricing