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10.1101/gad.284430.116 http://scihub22266oqcxt.onion/10.1101/gad.284430.116 C5002978!5002978 !27492368     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27492368 &cmd=llinks): Failed to open stream: HTTP request failed! 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Transcription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activation |pdf=|usr=}}{{27492368 }} gab.com Text Transcription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activation JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=27492368 #FOAvip The coordinated regulation of gene expression at the transcriptional level is fundamental to development and homeostasis. Inducible systems are invaluable when studying transcription because the regulatory process can be triggered instantaneously, allowing the tracking of ordered mechanistic events. Here, we use precision run-on sequencing (PRO-seq) to examine the genome-wide heat shock (HS) response in Drosophila and the function of two key transcription factors on the immediate transcription activation or repression of all genes regulated by HS. We identify the primary HS response genes and the rate-limiting steps in the transcription cycle that GAGA-associated factor (GAF) and HS factor (HSF) regulate. We demonstrate that GAF acts upstream of promoter-proximally paused RNA polymerase II (Pol II) formation (likely at the step of chromatin opening) and that GAF-facilitated Pol II pausing is critical for HS activation. In contrast, HSF is dispensable for establishing or maintaining Pol II pausing but is critical for the release of paused Pol II into the gene body at a subset of highly activated genes. Additionally, HSF has no detectable role in the rapid HS repression of thousands of genes. Twit Text FOAVip Transcription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activation ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=27492368 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27492368 #FOAvip English Wikipedia <ref>{{Cite pmid|27492368 }}</ref> Transcription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activation #MMPMID27492368 Duarte FM ; Fuda NJ ; Mahat DB ; Core LJ ; Guertin MJ ; Lis JT Genes Dev 2016[Aug]; 30 (15 ): 1731-46 PMID27492368 show ga The coordinated regulation of gene expression at the transcriptional level is fundamental to development and homeostasis. Inducible systems are invaluable when studying transcription because the regulatory process can be triggered instantaneously, allowing the tracking of ordered mechanistic events. Here, we use precision run-on sequencing (PRO-seq) to examine the genome-wide heat shock (HS) response in Drosophila and the function of two key transcription factors on the immediate transcription activation or repression of all genes regulated by HS. We identify the primary HS response genes and the rate-limiting steps in the transcription cycle that GAGA-associated factor (GAF) and HS factor (HSF) regulate. We demonstrate that GAF acts upstream of promoter-proximally paused RNA polymerase II (Pol II) formation (likely at the step of chromatin opening) and that GAF-facilitated Pol II pausing is critical for HS activation. In contrast, HSF is dispensable for establishing or maintaining Pol II pausing but is critical for the release of paused Pol II into the gene body at a subset of highly activated genes. Additionally, HSF has no detectable role in the rapid HS repression of thousands of genes. |Animals [MESH] |Cell Line [MESH] |DNA Polymerase II/metabolism [MESH] |DNA-Binding Proteins/genetics/*metabolism [MESH] |Drosophila Proteins/genetics/*metabolism [MESH] |Drosophila/*genetics/metabolism [MESH] |Gene Expression Regulation/*genetics [MESH] |Heat Shock Transcription Factors [MESH] |Promoter Regions, Genetic/genetics [MESH] |RNA Interference [MESH] |Stress, Physiological/*genetics [MESH]Transcription factors GAF and HSF act at distinct regulatory steps to (epmc).pdf DeepDyve Pubget Overpricing