How do meningeal lymphatic vessels drain the CNS? #MMPMID27460561
Raper D; Louveau A; Kipnis J
Trends Neurosci 2016[Sep]; 39 (9): 581-6 PMID27460561show ga
The many interactions between the nervous and the immune systems, which are active in both physiological and pathological states, have recently become more clearly delineated with the discovery of a meningeal lymphatic system capable of carrying fluid, immune cells and macromolecules from the CNS to the draining deep cervical lymph nodes. The exact localization of the meningeal lymphatic vasculature and the path of drainage from the CSF to the lymphatics remain, however, poorly understood. Here we discuss the potential differences between peripheral and CNS lymphatic vessels and examine the purported mechanisms of CNS lymphatic drainage, along with how these may fit into established patterns of CSF flow.