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10.1016/j.cell.2016.07.019 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.07.019 C5002269!5002269!27523608     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 166 (5): 1215-1230.e20 Nephropedia Template TP {{tp|p=27523608|t=2016. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity |pdf=|usr=}}{{27523608}} gab.com Text The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27523608 #FOAvip Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-?B, immune homeostasis, and responses to infection. The importance of negative regulators of M1-linked chains in vivo remains poorly understood. Here, we show that the M1-specific deubiquitinase OTULIN is essential for preventing TNF-associated systemic inflammation in humans and mice. A homozygous hypomorphic mutation in human OTULIN causes a potentially fatal autoinflammatory condition termed OTULIN-related autoinflammatory syndrome (ORAS). Four independent OTULIN mouse models reveal that OTULIN deficiency in immune cells results in cell-type-specific effects, ranging from over-production of inflammatory cytokines and autoimmunity due to accumulation of M1-linked polyubiquitin and spontaneous NF-?B activation in myeloid cells to downregulation of M1-polyubiquitin signaling by degradation of LUBAC in B and T cells. Remarkably, treatment with anti-TNF neutralizing antibodies ameliorates inflammation in ORAS patients and rescues mouse phenotypes. Hence, OTULIN is critical for restraining life-threatening spontaneous inflammation and maintaining immune homeostasis. Twit Text FOAVip The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27523608 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27523608 #FOAvip English Wikipedia <ref>{{Cite pmid|27523608}}</ref> The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity #MMPMID27523608 Damgaard R; Walker J; Marco-Casanova P; Morgan N; Titheradge H; Elliott P; McHale D; Maher E; McKenzie A; Komander D Cell 2016[Aug]; 166 (5): 1215-1230.e20 PMID27523608show ga Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-?B, immune homeostasis, and responses to infection. The importance of negative regulators of M1-linked chains in vivo remains poorly understood. Here, we show that the M1-specific deubiquitinase OTULIN is essential for preventing TNF-associated systemic inflammation in humans and mice. A homozygous hypomorphic mutation in human OTULIN causes a potentially fatal autoinflammatory condition termed OTULIN-related autoinflammatory syndrome (ORAS). Four independent OTULIN mouse models reveal that OTULIN deficiency in immune cells results in cell-type-specific effects, ranging from over-production of inflammatory cytokines and autoimmunity due to accumulation of M1-linked polyubiquitin and spontaneous NF-?B activation in myeloid cells to downregulation of M1-polyubiquitin signaling by degradation of LUBAC in B and T cells. Remarkably, treatment with anti-TNF neutralizing antibodies ameliorates inflammation in ORAS patients and rescues mouse phenotypes. Hence, OTULIN is critical for restraining life-threatening spontaneous inflammation and maintaining immune homeostasis. äThe Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflam(epmc).pdf DeepDyve Pubget Overpricing