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2016 ; 61
(7
): 847-60
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Epidemiology and economic burden of measles, mumps, pertussis, and varicella in
Germany: a systematic review
#MMPMID27488917
Damm O
; Witte J
; Wetzka S
; Prosser C
; Braun S
; Welte R
; Greiner W
Int J Public Health
2016[Sep]; 61
(7
): 847-60
PMID27488917
show ga
OBJECTIVES: Despite the availability of vaccines and the existence of public
vaccination recommendations, outbreaks of vaccine-preventable childhood diseases
still cause public health debate. The objective of this systematic review was to
provide an overview of the current epidemiology and economic burden of measles,
mumps, pertussis, and varicella in Germany. METHODS: We systematically reviewed
studies published since 2000. The literature search was conducted using PubMed
and EMBASE. Also, we used German notification data to give an up-to-date overview
of the epidemiology of the four diseases under consideration. RESULTS: Thirty-six
studies were included in our review. Results suggest that there is still
considerable morbidity due to childhood diseases in Germany. Studies providing
cost estimates are scarce. Comparative analyses of different data sources
(notification data vs. claims data) revealed a potential underestimation of
incidence estimates when using notification data. Furthermore, several studies
showed regional differences in incidence of some of the diseases under
consideration. CONCLUSIONS: Our findings underline the need for improved
vaccination and communication strategies targeting all susceptible age and risk
groups on a national and local level.