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10.1097/j.pain.0000000000000554

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C5001843!5001843 !26963844
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suck abstract from ncbi


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pmid26963844
      Pain 2016 ; 157 (7 ): 1499-1507
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  • A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component #MMPMID26963844
  • Atkinson JH ; Slater MA ; Capparelli EV ; Patel SM ; Wolfson T ; Gamst A ; Abramson IS ; Wallace MS ; Funk SD ; Rutledge TR ; Wetherell JL ; Matthews SC ; Zisook S ; Garfin SR
  • Pain 2016[Jul]; 157 (7 ): 1499-1507 PMID26963844 show ga
  • Gabapentin is prescribed for analgesia in chronic low back pain, yet there are no controlled trials supporting this practice. This randomized, 2-arm, 12-week, parallel group study compared gabapentin (forced titration up to 3600 mg daily) with inert placebo. The primary efficacy measure was change in pain intensity from baseline to the last week on treatment measured by the Descriptor Differential Scale; the secondary outcome was disability (Oswestry Disability Index). The intention-to-treat analysis comprised 108 randomized patients with chronic back pain (daily pain for ?6 months) whose pain did (43%) or did not radiate into the lower extremity. Random effects regression models which did not impute missing scores were used to analyze outcome data. Pain intensity decreased significantly over time (P < 0.0001) with subjects on gabapentin or placebo, reporting reductions of about 30% from baseline, but did not differ significantly between groups (P = 0.423). The same results pertained for disability scores. In responder analyses of those who completed 12 weeks (N = 72), the proportion reporting at least 30% or 50% reduction in pain intensity, or at least "Minimal Improvement" on the Physician Clinical Global Impression of Change did not differ significantly between groups. There were no significant differences in analgesia between participants with radiating (n = 46) and nonradiating (n = 62) pain either within or between treatment arms. There was no significant correlation between gabapentin plasma concentration and pain intensity. Gabapentin appears to be ineffective for analgesia in chronic low back pain with or without a radiating component.
  • |Adult [MESH]
  • |Aged [MESH]
  • |Amines/*therapeutic use [MESH]
  • |Analgesics/*therapeutic use [MESH]
  • |Chronic Pain/*drug therapy [MESH]
  • |Cyclohexanecarboxylic Acids/*therapeutic use [MESH]
  • |Disability Evaluation [MESH]
  • |Double-Blind Method [MESH]
  • |Female [MESH]
  • |Gabapentin [MESH]
  • |Humans [MESH]
  • |Low Back Pain/*drug therapy [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Pain Measurement [MESH]
  • |Treatment Outcome [MESH]


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