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10.1038/ncb3311 http://scihub22266oqcxt.onion/10.1038/ncb3311 C5001501!5001501!26854565     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2016 ; 18 (3): 319-27 Nephropedia Template TP {{tp|p=26854565|t=2016. Secreted IGFBP5 Mediates mTORC1-Dependent Feedback Inhibition of IGF-1 Signaling |pdf=|usr=}}{{26854565}} gab.com Text Secreted IGFBP5 Mediates mTORC1-Dependent Feedback Inhibition of IGF-1 Signaling JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26854565 #FOAvip The PI3K-Akt-mTORC1 pathway is a highly dynamic network that is balanced and stabilized by a number of feedback inhibition loops1, 2. Specifically, activation of mTORC1 has been shown to lead to the inhibition of its upstream growth factor signaling. Activation of the growth factor receptors is triggered by the binding of their cognate ligands in the extracellular space. However, whether secreted proteins contribute to the mTORC1-dependent feedback loops remains unclear. We found that cells with hyperactive mTORC1 secrete a protein that potently inhibits the function of IGF-1. Using a large-scale, unbiased quantitative proteomic platform, we comprehensively characterized the rapamycin-sensitive secretome in TSC2?/? MEFs, and identified IGFBP5 as a secreted, mTORC1 downstream effector protein. IGFBP5 is a direct transcriptional target of HIF1, which itself is a known mTORC1 target3. IGFBP5 is a potent inhibitor of both the signaling and functional outputs of IGF-1. Once secreted, IGFBP5 cooperates with intracellular branches of the feedback mechanisms to block the activation of IGF-1 signaling. Finally, IGFBP5 is a potential tumor suppressor, and the proliferation of IGFBP5-mutated cancer cells are selectively blocked by IGF-1R inhibitors. Twit Text FOAVip Secreted IGFBP5 Mediates mTORC1-Dependent Feedback Inhibition of IGF-1 Signaling ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26854565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26854565 #FOAvip English Wikipedia <ref>{{Cite pmid|26854565}}</ref> Secreted IGFBP5 Mediates mTORC1-Dependent Feedback Inhibition of IGF-1 Signaling #MMPMID26854565 Ding M; Bruick RK; Yu Y Nat Cell Biol 2016[Mar]; 18 (3): 319-27 PMID26854565show ga The PI3K-Akt-mTORC1 pathway is a highly dynamic network that is balanced and stabilized by a number of feedback inhibition loops1, 2. Specifically, activation of mTORC1 has been shown to lead to the inhibition of its upstream growth factor signaling. Activation of the growth factor receptors is triggered by the binding of their cognate ligands in the extracellular space. However, whether secreted proteins contribute to the mTORC1-dependent feedback loops remains unclear. We found that cells with hyperactive mTORC1 secrete a protein that potently inhibits the function of IGF-1. Using a large-scale, unbiased quantitative proteomic platform, we comprehensively characterized the rapamycin-sensitive secretome in TSC2?/? MEFs, and identified IGFBP5 as a secreted, mTORC1 downstream effector protein. IGFBP5 is a direct transcriptional target of HIF1, which itself is a known mTORC1 target3. IGFBP5 is a potent inhibitor of both the signaling and functional outputs of IGF-1. Once secreted, IGFBP5 cooperates with intracellular branches of the feedback mechanisms to block the activation of IGF-1 signaling. Finally, IGFBP5 is a potential tumor suppressor, and the proliferation of IGFBP5-mutated cancer cells are selectively blocked by IGF-1R inhibitors. äSecreted IGFBP5 Mediates mTORC1-Dependent Feedback Inhibition of IGF-1(epmc).pdf DeepDyve Pubget Overpricing